Jimmy C. Lu MD, Presenter: Nothing to Disclose

Adam L. Dorfman MD, Abstract Co-Author: Nothing to Disclose

Maryam Ghadimi Mahani MD, Abstract Co-Author: Nothing to Disclose

Prachi P. Agarwal MD, Abstract Co-Author: Nothing to Disclose

To illustrate how strain, a measure of myocardial deformation, can quantify regional and global ventricular dysfunction and dyssynchrony. To describe methods of strain measurement on cardiac magnetic resonance imaging. To understand the literature on decreased strain as an early indicator of clinical outcomes in multiple cohorts of pediatric and congenital heart disease.

I. Definition of strain    A. Lagrangian vs. Eulerian    B. Longitudinal, circumferential and radial    C. Segmental vs. Global II. Measurement methods: Advantages and limitations    A. Harmonic phase analysis (HARP)    B. Feature tracking (FT) III. Applications in pediatric and congenital heart disease    A. Cardiomyopathies       1. Duchenne muscular dystrophy: Strain vs. ejection fraction and late gadolinium enhancement (LGE)       2. Anthracycline toxicity: Strain as an early indicator of dysfunction       3. Hypertrophic cardiomyopathy: Relation of strain to LGE, hypertrophy, and clinical outcomes    B. Congenital heart disease       1. Tetralogy of Fallot          a. Dyssynchrony predicts clinical outcomes          b. Right ventricular strain relates to quality of life and exercise capacity       2. Single ventricle physiology: abnormal mechanics compared to two ventricle physiology IV. Conclusion

http://abstract.rsna.org/uploads/2014/14006568/14006568_glkf.pdf

Lu, J, Dorfman, A, Ghadimi Mahani, M, Agarwal, P, Cardiovascular Magnetic Resonance Evaluation of Ventricular Strain in Pediatric and Congenital Heart Disease.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006568.html