Yurong Zhou PhD, Presenter: Nothing to Disclose

Xiaoming Yang MD, PhD, Abstract Co-Author: Nothing to Disclose

Jihong Sun MD, PhD, Abstract Co-Author: Nothing to Disclose

Guocan Han, Abstract Co-Author: Nothing to Disclose

Yue Wang, Abstract Co-Author: Nothing to Disclose

ZhiMing Li, Abstract Co-Author: Nothing to Disclose

To validate the feasibility of using molecular MRI/ radiofrequency heat (RFH) to improve chemotherapeutic effects on breast cancers.

Human breast cancer cells (Bcap-37) and 24 tumor-bearing mice were divided into four groups: (i) no treatment as a control; (ii) RFH-only; (iii) doxorubicin (ADM)-only; and (iv) combination therapy of ADM plus RFH. RFH was performed by using a 0.032-inch MRI heating-guidewire (MRIHG) at 42℃ for 20 minutes. Cell proliferation and apoptosis were evaluated in vitro. Changes of tumor masses were monitored in vivo by MRI overtime, with subsequent histological correlation.

Of in-vitro confirmation, cell proliferation in the combination therapy group decreased significantly compared to those in other three groups with no treatment, RFH-only and ADM-only (0.62±0.04 VS 1.19±0.02 VS 1.00±0.07 VS 0.71±0.07, P<0.05), while apoptosis index increased correspondingly (55.37±13.99% VS 1.61±0.53% VS 3.32±0.61% VS 43.32±15.47%, P <0.05). Of in-vivo validation, MRI showed a significant decrease of tumor size in the combination therapy group compared to those in saline, RFH-only and ADM-only groups, which were confirmed by histology (89.12±34.73mm3 VS 639.90±269.30mm3 VS 373.90±161.60mm3 VS 334.80±115.90mm3, P <0.05).

MRIHG-mediated RFH can enhance the killing effect of doxorubicin on breast cancers, which may open new avenues in efficient treatment of breat malignancies by molecular MR/RF-integrated interventional oncology and chemotherapy.

MRIHG-mediated RFH technique may open new avenues in efficient treatment of breat malignancies by molecular MR/RF-integrated interventional oncology and chemotherapy.

Zhou, Y, Yang, X, Sun, J, Han, G, Wang, Y, Li, Z, Interventional Molecular MRI/Radiofrequency Heat-Enhanced Chemotherapy of Breast Cancer.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006456.html