Fabiana Ferrari MD, Presenter: Nothing to Disclose

Anna Miccoli MD, Abstract Co-Author: Nothing to Disclose

Francesco Arrigoni, Abstract Co-Author: Nothing to Disclose

Eva Fascetti MD, Abstract Co-Author: Nothing to Disclose

Antonio Barile MD, Abstract Co-Author: Nothing to Disclose

Carlo Masciocchi MD, Abstract Co-Author: Nothing to Disclose

To evaluate the efficacy of MRgFUS in the uterine fibroids treatment analysing the recurrence rate after 12 months from the treatment. This study correlates the age of patients to the clinical and imaging results.

38 patients, with symptomatic uterine fibroids were treated using MRgFUS from September 2011 to December 2012. Twenty-two of them were aged between 40 and 50 (group 1), 10 patients between 30 and 40(group 2) and 6 patients between 20 and 30 (group 3). Single fibroids were found in 13 patients while 25 patients presented multiple fibroids. Patients were submitted to one treatment alone. We submitted the patients to c.e. MRI respectively before treatment, after 10 days, 3 months, 6 months and 12 months. We made a morphological analysis of the images, an evaluation of the treated volume extension and the possible recurrence of the pathology in the area of the treatment. Clinical evaluation was performed by SSS-questionnaire, comparing the pre-treatment score to the one obtained after 12 months.

All patients had a non-perfused-volume mean value of 91.5 %. Thirty-four women belonging to Group 1, Group 2 and Group 3 (89.5% of patients) showed a complete reabsorption of the necrotic area without any fibrotic tissue in the treatment area after 12 months. Four younger women (10.5 % of patients) belonging to Group 3, aged between 24 and 30 years, showed hypointense tissue in the peripherical part of the treated area after 3-6 months from the treatment. One of them, who underwent myomectomy, showed a mixed tissue made of necrotic cells and fibrotic tissue. Clinically, after 12 months from the treatment, Group 1, Group 2, and Group 3 showed a SSS-Q mean value of 7.8, 8.1, and 6.4, respectively. We did not appreciate clinical differences of statistical relevance between the groups.

MRgFUS is an effective technique in younger and older women. We found excellent morphological results and clinical outcomes in patients belonging to group 1 and 2. In Group 3, the excellent clinical response was not associated to significant morphological results, this however not impairing the final response to the treatment.

We evaluate the efficacy of the uterine fibroid treatment using MRgFUS correlating the morphological and clinical results in younger and older women obtaining in both groups good therapeutic results.

Ferrari, F, Miccoli, A, Arrigoni, F, Fascetti, E, Barile, A, Masciocchi, C, Retrospective Study of Uterine Fibroid Treatment Using MRgFUS: Correlations between Age, Recurrence Rate and Clinical Outcomes.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006454.html