Thomas Josef Vogl MD, PhD, Presenter: Nothing to Disclose

Alena Dommermuth BS, Abstract Co-Author: Nothing to Disclose

Britta Heinle, Abstract Co-Author: Nothing to Disclose

Nour-Eldin Abdelrehim Nour-Eldin MD, MSc, Abstract Co-Author: Nothing to Disclose

Thomas Lehnert MD, Abstract Co-Author: Nothing to Disclose

Stefan Zangos MD, Abstract Co-Author: Nothing to Disclose

Wolf-Otto Bechstein, Abstract Co-Author: Nothing to Disclose

Nagy Naguib Naeem Naguib MD, MSc, Abstract Co-Author: Nothing to Disclose

To evaluate the prognostic factors for long-term survival and progression-free survival (PFS) after treatment of colorectal cancer (CRC) liver metastases with MR-guided laser-induced thermotherapy (LITT).

We included 594 patients (mean age, 61.2 years) with CRC liver metastases who were treated with LITT. The statistical analysis of long-term survival and PFS were based on the Kaplan-Meier method. The Cox regression model tested different parameters that could be of prognostic value. The tested prognostic factors were the following: sex, age, location of primary tumor, number of metastases, maximum diameter and total volume of metastases and necroses, quotient of total volumes of metastases and necroses, time of appearance of liver metastases and location in the liver, TNM classification of CRC, extrahepatic metastases, and neoadjuvant treatment.

Median survival was 25 months starting from the date of the first LITT. The 1-, 2-, 3-, 4-, and 5-year PFS rates were 51.3%, 35.4%, 30.7%, 25.4%, and 22.3%, respectively. The number of metastases and their maximum diameter were the most important prognostic factors for both long-term survival and PFS. Long-term survival was also highly influenced by the initial involvement of the lymph nodes.

For patients treated with LITT for CRC liver metastases, the number and size of metastases, together with the initial lymph node status, are significant prognostic factors for long-term survival.

MR-guided LITT allows an excellent local control of liver metastases in colorectal cancer

Vogl, T, Dommermuth, A, Heinle, B, Nour-Eldin, N, Lehnert, T, Zangos, S, Bechstein, W, Naguib, N, Long-term and Progression-free Survival in Colorectal Cancer Liver Metastases after Thermal Ablation Using MR-guided Laser-induced Thermotherapy in 594 Patients: Analysis of Prognostic Factors.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006440.html