Yoshifumi Noda MD, Presenter: Nothing to Disclose

Satoshi Goshima MD, PhD, Abstract Co-Author: Nothing to Disclose

Hiroshi Kondo MD, Abstract Co-Author: Nothing to Disclose

Haruo Watanabe MD, Abstract Co-Author: Nothing to Disclose

Hiroshi Kawada MD, Abstract Co-Author: Nothing to Disclose

Nobuyuki Kawai MD, Abstract Co-Author: Nothing to Disclose

Yukichi Tanahashi MD, Abstract Co-Author: Nothing to Disclose

Masayuki Kanematsu MD, Abstract Co-Author: Nothing to Disclose

Kyongtae Tyler Bae MD, PhD, Abstract Co-Author: Patent agreement, Covidien AG Consultant, Otsuka Holdings Co, Ltd

To assess the potential value of magnetic resonance (MR) imaging in evaluating the progression of type 2 diabetes mellitus (T2DM) and correlation with pathological features.

This retrospective study was approved by our institutional review board and written informed consent was waived. MR imaging obtained in 29 consecutive patients (15 men, 14 women; mean age, 67.5 ± 11.8 years; range, 22–80 years) who underwent pancreatectomy were evaluated. Patients were classified into three groups according to the following HbA1c value: HbA1c ≥ 6.5 (T2DM), 5.7 ≤ HbA1c < 6.5 (pre-T2DM), HbA1c < 5.7 (non-T2DM). The pancreas-to-muscle signal intensity ratio (SIR) on in- and opposed-phase images, T2- and diffusion-weighted images, and the apparent diffusion coefficient (ADC) of the pancreas were measured. MR imaging parameters were correlated with the degree of islet amyloid polypeptide (IAPP) deposition and pancreatic fibrosis using multiple regression analysis. The relationships between the severity of T2DM and the MR imaging measurements were examined by using multiple regression analysis and the one-way analysis of variance.

Multiple regression analysis demonstrated that SIRs on opposed- and in-phase images were independently associated with IAPP deposition (P = .0044) and with pancreatic fibrosis (P = .0002), and SIR on opposed-phase images was associated with the severity of T2DM (P = .0001). Compared with the patients with pre- or non-T2DM, those with T2DM demonstrated significantly lower SIR on in- and opposed-phase images (P < .05), and the odds ratio for the presence of T2DM was 52.0 in patients with the cutoff SIR value of 1.08.

The SIR on in- and opposed-phase images of the pancreas can be a potential biomarker for assessment of IAPP deposition, pancreatic fibrosis, and the severity of T2DM.

Our study demonstrated the SIR on opposed-phase images of the pancreas possibly represent the IAPP deposition and severity of T2DM. This index may be an important quantitative biomarker for the screening of patients with impaired glucose tolerance.

Noda, Y, Goshima, S, Kondo, H, Watanabe, H, Kawada, H, Kawai, N, Tanahashi, Y, Kanematsu, M, Bae, K, Pancreas Signal Intensity in Patients with Type 2 Diabetes Mellitus: Correlation with Pathological Features.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006341.html