Bo Wang MMed, Presenter: Nothing to Disclose

Kunhua Wu MMed, Abstract Co-Author: Nothing to Disclose

Abnormal brain iron deposition was observed at the subclinical stage of PD patients. Pathologic iron deposition locations included SNc, SNr and RN, but not GP, PUT，CN, THA or FWM. SWI provide useful information in the detection of brain iron deposition, therefore, it may be applied in the early diagnosis of PD. 

Parkinson disease (PD) is a degenerative disease of CNS which has great impact on elderly people. The purpose of this study is to quantitatively evaluate the variations of T2* values in several cerebral regions and to devise a potential applicable method for the early diagnosis of Parkinson disease (PD) applying susceptibility weighted imaging (SWI). 

Fifty-nine hemi-PD patients and Fifty-nine healthy control subjects were recruited and underwent routine scanning and SWI on 3T (GE Signa HD, WI). The age and gender of the subjects were matched between patient and control groups. T2* value was measured bilaterally in substantia nigra pars compacta (SNc), substantia nigra pars reticulata (SNr), red nucleus (RN), globus pallidus (GP), putamen (PUT), head of caudate nucleus (CN), thalamus (THA) and frontal white matter(FWM).

T2* values varied significantly in the region of SNc (P<0.05) between two groups, whereas corresponding no inter-group difference was observed in the regions of SNr, GP, PUT, CN，THA or FWM ipsilaterally.. Comparing ipsilateral hemi-PD patients with contralateral control subjects, T2* values were significantly different in SNc (P<0.01) and SNr (P<0.05), whereas no statistical significant differences were observed in GP, PUT, CN, THA or FWM. Comparing hemi-PD patients contralaterally with control subjects contralaterally, T2* values were significantly different in the regions of the SNc and RN (P<0.05), with no observed differences in GP, PUT, CN, THA or FWM. No significant difference of T2* values was demonstrated in any targeted regions between hemi-PD patients contralaterally and control subjects ipsilaterally.  Fig. Cerebral SNc, SNr, RN magnified color figure of T2*and it’s graphics resolution of ROI in the normal subjects. 

Wang, B, Wu, K, Evaluating Regional T2* Values in the Early Diagnosis of Parkinson Disease Using Susceptibility Weighted Imaging.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006337.html