Matthew Harlan Lee MD, Presenter: Nothing to Disclose

Cristopher A. Meyer MD, Abstract Co-Author: Stockholder, Cellectar Biosciences, Inc

Jeffrey P. Kanne MD, Abstract Co-Author: Research Consultant, Perceptive Informatics, Inc

- Disorders of humoral immunity result in a variety of clinically significant immunoglobulin (Ig) related diseases. - Identify representative Ig related diseases and their characteristic thoracic imaging findings. - Demonstrate how familiarity with Ig related diseases informs thoracic imaging findings and narrows differential diagnosis.  

- Introduction with overview of antibody-mediated immunity, specific Ig function, autoimmunity, and basic mechanisms underlying autoimmunity. - Illustrate Ig related diseases with overview and discussion of clinical manifestations, serologic profiles (i.e. increased/decreased Ig subtype), and typical radiographic and CT findings. Examples: Primary immune deficiency: Agammaglobulinemia, common variable immunodeficiency, IgA and IgG deficiency. Autoimmune: IgG4 and IgG3 related disease, IgA nephropathy, Goodpasture disease, pulmonary alveolar proteinosis. Allergy related: ABPA. Plasma cell disorder: Multiple myeloma/MGUS. Drug related: antibody therapies. Other: Amyloid, light chain deposition disorder. Summary: - A myriad of Ig related diseases have thoracic manifestations. - Recognizing the imaging findings of Ig related diseases and their specific serologic profiles aids in establishing a specific diagnosis or limiting differential diagnosis.      

http://abstract.rsna.org/uploads/2014/14006311/14006311_28ho.pdf

Lee, M, Meyer, C, Kanne, J, Evil Humors: Thoracic Manifestations of Immunoglobulin Related Disease in Adults.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006311.html