Ali Murat Koc MD, Presenter: Nothing to Disclose

Ali Yusuf Oner MD, Abstract Co-Author: Nothing to Disclose

Halil Ozer, Abstract Co-Author: Nothing to Disclose

R?dvan Mercan, Abstract Co-Author: Nothing to Disclose

Berivan Bitik, Abstract Co-Author: Nothing to Disclose

Mehmet Akif Ozturk MD, Abstract Co-Author: Nothing to Disclose

E. Turgut Tali MD, Abstract Co-Author: Nothing to Disclose

Conventional, dynamic contrast enhanced imaging (DCE) and diffusion MRI of the sacroiliac joints has been widespreadly used in the daily clinical practice. Permeability measures has became calculable through DCE, are used in various CNS pathologies. The purpose of this paper is to compare these permeability measures derived from DCE with conventional, contrast enhanced and diffusion MRI techniques in diagnosis of patients with sacroiliitis (SI) at 3T.

An institutional review board approval was obtained for this study. A total of 20 patients with SI were included. All patients were evaluated with routine laboratory exams, spesific scoring methods (VAS, BASFI, BASDAI, ASQoL, BASMI) for disease activity and ASAS criteria at the rheumatology clinic before referral. Conventional (including T1, T2W and STIR images), dynamic contrast enhanced imaging with gadoterate meglumine and diffusion sequences were performed for each patient at 3T. ADC values from DWI; Ktrans, Kep and TTP values from DCE images were calculated, respectively. Quantitative evaluation was performed for the data driven from DCE time-intensity curve, ADC map and values of permeability by means of ROI placed within areas of bone marrow edema and contralateral normal appearing bone with the help of conventional images. Quantitative values obtained were statistically evaluated and correlated with disease activity scores obtained from the clinical evaluation methods.

Conventional, diffusion weighted and DCE images had successfully defined regions of edema and increased contrast uptake. Clinical scores of disease activity also showed good correlation with permeability values in all patients. Ktrans, Kep and TTP values showed greater difference between regions of bone marrow edema and contralateral normal appearing bone and correlated well with ADC measurements.

This initial repot showed that permeability calculation of DCE is a promising technique in imaging of SI and can be usefull in establishing radiological correlation with disease activity.

Permeability calculation of DCE in sacroiliac imaging is a promising technique which is expected to help early diagnosis, management of treatment and follow up procedures in SI.

Koc, A, Oner, A, Ozer, H, Mercan, R, Bitik, B, Ozturk, M, Tali, E, Permeability Imaging in Sacroiliitis: Initial Report.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006151.html