Shao Wu Wang MD, Abstract Co-Author: Nothing to Disclose

Minting Zheng, Presenter: Nothing to Disclose

Dianxiu Ning MD, Abstract Co-Author: Nothing to Disclose

Yue Dong, Abstract Co-Author: Nothing to Disclose

Zhang Lina, Abstract Co-Author: Nothing to Disclose

yingzi wang, Abstract Co-Author: Nothing to Disclose

To investigate the statistical correlation between Apparent Diffusion Coefficients(ADCs) of MR-DWI and histopathologic grade of soft tissue sarcomas(STSs).

1.Case data: 33 cases of STSs were chosen for surgical treatment. 2.Equipment and technology: DWI(b=600s/mm2) scanned before the DCE-MRI, the lesion site was fixed. 3.DWI post-processing and data collection: Functool functional software was used to post-process the original image, each of them were worked with the ROI-1 and ROI-2, recording ADCs on the ADC reconstruction maps respectively. 4. Observational indexes: (1) ADCs of STSs : including minimum ADCs(average 3 minimum ADCs from ROI-1) and average ADCs(average all of the average ADCs from ROI-2).  (2) The histopathological grade of STSs : accroding to the histopathological grading system of French Federation Cancer Centre, we classified STSs into grade I、II、III. (3) According to mucinous in STSs pathological diagnosis, we divide STSs into myxoid and non-myxoid groups.

1.As STSs histopathological grade increased, Minimum ADCs and Average ADCs decreased gradually.But there was no significant difference with ADCs among 9 cases of grade I, 13 cases of grade II and 11 cases of grade III (p>0.05) . 2. Average ADCs of 13 myxoid STSs was significantly higher than the other 20 with non-myxoid STSs,when Average ADCs is 1.357×10-3 mm2/s,they were identified with the sensitivity of 76.9% and specificity of 80.0%;Minimum ADCs of the myxoid STSs was higher than the non-myxoid STSs, but the difference was not significant (p> 0.05). 3. Minimum ADCs and histopathological level of 20 non-myxoid STSs cases were negatively correlated (r = -0.824, P = 0.000).there were significant difference between the non-myxoid STSs of each grade(p <0.05); there were no significant difference in average ADCs between non-myxoid STSs of each grade (p> 0.05); and also no significant difference in minimum ADCs、average ADCs between myxoid STSs of each grade (p> 0.05).

1.As STSs pathological level increased, Minimum ADCs and Average ADCs decreased gradually, but we can not identify STSs histopathological level based on Minimum ADCs and Average ADCs. 2.Average ADCs of myxoid STSs was higher than that of non-myxoid STSs. 3.Minimum ADCs can show the histopathological grading of non-myxoid STSs.

ADCs of MR-DWI can reflect histopathologic grade of STSs.

Wang, S, Zheng, M, Ning, D, Dong, Y, Lina, Z, wang, y, A Comparative Study for Soft Tissue Sarcoma between Diffusion Weighted Imaging and Histopathology.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14006033.html