Kazunari Ishii MD, Presenter: Nothing to Disclose

Chisa Hosokawa MD, Abstract Co-Author: Nothing to Disclose

Tomoko Hyodo MD, Abstract Co-Author: Nothing to Disclose

Hiroto Takahashi, Abstract Co-Author: Nothing to Disclose

Nobuo Kashiwagi, Abstract Co-Author: Nothing to Disclose

Takamichi Murakami MD, PhD, Abstract Co-Author: Nothing to Disclose

Mitsuru Matsuki, Abstract Co-Author: Nothing to Disclose

Ryuichiro Ashikaga MD, Abstract Co-Author: Nothing to Disclose

1. To review the pathophysiology of dementia with Lewy bodies (DLB). 2. To learn the characteristic structural and functional image findings of DLB. Structural and functional imaging biomarkers: brain MRI and SPECT/PET functional imaging have an important role in diagnosing DLB. 3. To show representative MRI, Brain perfusion SPECT, MIBG myocardial scintigraphy, dopamine transporter imaging, FDG-PET and PiB PET images of DLB comparing with those of Alzheimer disease (AD). 4. To show interpretation pitfalls in diagnosing DLB by MR, and SPECT/PET images.  

Pathophysiology of DLB: DLB is the second most common neurodegenerative dementia accompanying Lewy bodies in the brainstem and cerebral cortices, though it is not well recognized by general radiologists. Characteristic findings of DLB: relative preservation of medial temporal lobe structures, occipital hypoperfusion/hypometabolism associated with parietotemporal and posterior cingulated hypoperfusion/hypometabolism, low dopamine transporter uptake in the basal ganglia, unnecessary neocortical amyloid deposit and low uptake of MIBG myocardial scintigraphy. Characteristic findings of Alzheimer disease (AD) for discrimination. Present a pictorial essay of DLB and AD on MRI and SPECT/PET images. Illustrate imaging pitfalls resulting from misdiagnosis of DLB and AD.  

http://abstract.rsna.org/uploads/2014/14005897/14005897_md7g.pdf

Ishii, K, Hosokawa, C, Hyodo, T, Takahashi, H, Kashiwagi, N, Murakami, T, Matsuki, M, Ashikaga, R, Diagnosis of Dementia with Lewy Bodies (DLB) with Neuroimaging Techniques.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14005897.html