Qingqiang Zhu, Presenter: Nothing to Disclose

To characterize Magnetic Resonance Diffusion Kurtosis Imaging (DKI) in the study of renal angiomyolipoma with minimal fat and clear cell renal cell carcinoma.

19 patients with renal angiomyolipoma with minimal fat and 24 patients with clear cell renal cell carcinoma were retrospectively studied. Tumor DKI features (b value=0, 300, 600 s/mm2 ), including Mean Diffusivity ( MD), Fractional Anisotropy (FA), mean kurtosis ( MK), radial kurtosis (RK), kurtosis anisotropy (KA), were assessed and investigated. Evaluated DKI features were compared between two tumor types by applying independent-sample t test.

Statistically significant differences were observed in the properties under evaluation between renal angiomyolipoma with minimal fat and clear cell renal cell carcinoma group and roup. MD: (1.48±0.46 vs 7.13±1.19, P<0.05)；FA: (0.76±0.12 vs 0.728±0.113, P>0.05)； MK: (1.76±1.42 vs 0.336±0.26, P<0.05)；KA: (1.42±0.66 vs 0.49±0.13, P<0.05)；RK: (5.88±3.26 vs 0.33±0.22, P<0.05). For differentiating renal angiomyolipoma with minimal fat from clear cell renal cell carcinoma, combined evaluation of MD, FA, MK, KA and RK features was found to have a accuracy of 97.7%.  

Our initial results indicate the feasibility of DKI in in differentiating renal angiomyolipoma with minimal fat from clear cell renal cell carcinoma. Future studies in patients with kidney diseases are required to determine the value of DKI for functional kidney imaging.

Strictly limited amount of topics involving DKI method in the study of renal oncology. And this is the only option throughout the section. Our initial results indicate the feasibility of DKI in in differentiating renal angiomyolipoma with minimal fat from clear cell renal cell carcinoma. Future studies in patients with kidney diseases are required to determine the value of DKI for functional kidney imaging.

Zhu, Q, Magnetic Resonance Diffusion Kurtosis Imaging in Differential Diagnosis of Renal Angiomyolipoma with Minimal Fat and Clear Cell Renal Cell Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14005830.html