Azusa Kitao, Presenter: Nothing to Disclose

Osamu Matsui MD, Abstract Co-Author: Research Consultant, Kowa Company, Ltd Research Consultant, Otsuka Holdings Co, Ltd Research Consultant, Eisai Co, Ltd Speakers Bureau, Bayer AG Speakers Bureau, Eisai Co, Ltd

Toshifumi Gabata MD, Abstract Co-Author: Nothing to Disclose

Norihide Yoneda, Abstract Co-Author: Nothing to Disclose

Kazuto Kozaka MD, Abstract Co-Author: Nothing to Disclose

Satoshi Kobayashi MD, Abstract Co-Author: Nothing to Disclose

Dai Inoue, Abstract Co-Author: Nothing to Disclose

Kotaro Yoshida MD, Abstract Co-Author: Nothing to Disclose

Tetsuya Minami MD, Abstract Co-Author: Nothing to Disclose

Wataru Koda, Abstract Co-Author: Nothing to Disclose

The purpose of this presentation is 1. To review that the hepatobiliary phase of gadoxetic acid enhanced MR imaging is a sensitive (indirect) molecular imaging reflecting expression of uptake transporter organic anion transporting polypeptide 1B3 (OATP1B3) in hepatocellular carcinoma (HCC). 2. To demonstrate that the signal intensity on hepatobiliary phase reflects biological and molecular/genetic characteristics of HCC. 3. To discuss the possibility of gadoxetic acid enhanced MR imaging for personalized medicine in HCC as an imaging biomarker from “radiogenomics” point of view.

1. Enhancement mechanism of gadoxetic acid enhanced MR imaging in HCC - Correlation between OATP1B3 expression and signal intensity - Changes in enhancement ratio and OATP1B3 expression in multistep hepatocarcinogenesis 2. Biological and molecular/genetic characteristics of hypointense (OATP1B3 under-expressed) HCC and hyperintense (OATP1B3 over-expressed) HCC - Clinical and pathological findings - Molecular and genetic analysis - Role of transcription factor hepatocyte nuclear factor (HNF) 4A in hepatocarcinogenesis 3. Usefulness of gadoxetic acid enhanced MR imaging for personalized medicine in HCC as an imaging biomarker expressing some specific molecular/genetic backgrounds (radiogenomics)

http://abstract.rsna.org/uploads/2014/14005312/14005312_v7m1.pdf

Kitao, A, Matsui, O, Gabata, T, Yoneda, N, Kozaka, K, Kobayashi, S, Inoue, D, Yoshida, K, Minami, T, Koda, W, Correlation between Gadoxetic Acid Enhanced MR Imaging and Molecular/Genetic Background of Hepatocellular Carcinoma: Implication for Radiogenomics.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14005312.html