Teresa Cabada MD, Presenter: Nothing to Disclose

Ana Sanchez, Abstract Co-Author: Nothing to Disclose

Pablo Lecumberri, Abstract Co-Author: Nothing to Disclose

Lucia Moreno, Abstract Co-Author: Nothing to Disclose

Carmen Bacaicoa, Abstract Co-Author: Nothing to Disclose

Marisol Gomez, Abstract Co-Author: Nothing to Disclose

Manuel Cuesta, Abstract Co-Author: Nothing to Disclose

to determine the relationship between cortical volumes and cognition in first episode psychosis (FEP) patients

Twenty FEP patients were assessed with the Screen for Cognitive Impairment in Psychiatry1 (SCIP), a brief cognitive test which assesses immediate and delayed verbal memory, working memory, verbal fluency and processing speed. All participants underwent MRI scanning on a 1.5 T Siemens Avanto scanner. High resolution structural T1-weighted images were acquired. Cortical reconstruction and volumetric segmentation was performed with the Freesurfer® image analysis suite (http://surfer.nmr.mgh.harvard.edu/). Its processing includes parcellation of the cerebral cortex into units based on gyral and sulcal structure and computation of cortical thickness at each vertex on the tessellated pial surface. Pearson correlations were calculated to assess the association between the SCIP and global cortical volume and different cortical areas. Partial correlations were calculated to control for the effects of lifetime antipsychotic treatment  

Pearson correlations showed significant associations between working memory SCIP subtest and cortex volume (p=0.000), right and left cerebellum volume (p=0.04 and p=0.029 respectively), right and left amygdale volume (p=0.03 and p=0.001 respectively), and right and left hippocampus volume (p=0.014 and p=0.031 respectively). When controlling for antipsychotic treatment, significant correlations were found between the total score of the SCIP and cortex volume (p=0.001), left and right amygdala volume (p=0.004 and p=0.001 respectively) and right hippocampus volume (p=0.031).  

Global cortical volume and cerebellum, amygdale and hippocampus volumes may be related to cognitive performance in the early phases of psychosis.  

Impaired cognition can be observed in early phases of psychosis and it shows a relationship with some cortical structures volumes

Cabada, T, Sanchez, A, Lecumberri, P, Moreno, L, Bacaicoa, C, Gomez, M, Cuesta, M, Cortex Volumetry and Cognition in First Episode Psychosis Patients.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14005099.html