Ernst Michael Jung MD, Presenter: Nothing to Disclose

Stefan Schleder MD, Abstract Co-Author: Nothing to Disclose

Lena Dendl, Abstract Co-Author: Nothing to Disclose

Christian Roland Stroszczynski MD, Abstract Co-Author: Nothing to Disclose

To evaluate the impact of high-resolution contrast-enhanced ultrasound (CEUS) in combination with Color Coded and Power Doppler Sonography (CCDS/PD) in the preoperative differentiation of thyroid adenomas and thyroid carcinomas.

A total of 111 patients (60 female, median age 54 years) underwent surgery for thyroid adenoma and thyroid carcinoma. CCDS/PD and CEUS were performed in all patients by an experienced examiner using amultifrequency linear transducer (6-9 MHz) and were digitally stored.Reading of the ultrasound images was performed by two experienced radiologistsin consensus. For CEUS a bolus injection of 1 ml Sulfurhexaflouride-Microbubbles (SonoVue®) was used. A histopathological evaluation was obtained as standard of reference in all patients.

80 thyroid adenomas and 31 thyroid carcinomas were detected. Mean diameter of thyroid adenomas and thyroid carcinomas was 27 mm and 25 mm, respectively. The differences in microcirculation of thyroid adenomas and thyroid carcinomas werestatistically highly significant (p <0.01). Representative features for thyroid adenomas were either no wash-out or wash-out with persisting edge in late phase, for thyroid carcinomas a complete wash-out in late phase. Thus, calculation of the sensitivity, specificity, positive and negative predictive value of 82%, 91%, 96% and 63%, respectively, for the differentiation of benignity and malignancy was possible.

Dynamic evaluation of microcirculation using CEUS and CCDS/PD enables a more reliable preoperative discrimination between thyroid adenomas and thyroid carcinomas.

CEUS enables a more reliable preoperative discrimination between thyroid adenomas and thyroid carcinomas

Jung, E, Schleder, S, Dendl, L, Stroszczynski, C, Preoperative Differentiation of Thyroid Adenomas and Thyroid Carcinomas Using High Resolution Contrast-enhanced Ultrasound (CEUS).  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14004848.html