Derek William Cool MD, PhD, Presenter: Patent agreement, Eigen

Eli Gibson MSc, Abstract Co-Author: Nothing to Disclose

Mena Gaed MD, Abstract Co-Author: Nothing to Disclose

Jose A. Gomez, Abstract Co-Author: Nothing to Disclose

Madeleine Moussa, Abstract Co-Author: Nothing to Disclose

Aaron D. Ward PhD, Abstract Co-Author: Nothing to Disclose

Aaron Fenster PhD, Abstract Co-Author: License agreement, Eigen

Stephen E. Pautler MD, Abstract Co-Author: Nothing to Disclose

Joseph Chin MD, Abstract Co-Author: Nothing to Disclose

Jonathan Izawa, Abstract Co-Author: Nothing to Disclose

Glenn Baumann MD, Abstract Co-Author: Nothing to Disclose

Cesare Romagnoli MD, Abstract Co-Author: Consultant, Profound Medical Inc

This educational exhibit discusses the European Society of Urogenital Radiology (ESUR) PIRADS framework for MP-MRI interpretation through rad-path correlation. All rad-path correlation was achieved through fiducial-based MRI-to-histology registration post-prostatectomy or through MRI-TRUS fusion biopsy. 1. Non-malignant lesions, such as prostatitis, BPH nodules or prostatic intraepithelial neoplasia (PIN), can mimic prostate adenocarcinoma (PCa) on MP-MRI. 2. PIRADS has been developed to standardize and improve MP-MRI interpretation by providing an estimate of malignancy from 1-5. 3. MP-MRI interpretation within the peripheral zone of the prostate differs from interpretation of the central/transitional zone of the prostate. Low ADC is the most reliable predictor of malignancy in the peripheral zone. T2 is the most reliable for differentiating malignancy from BPH nodules in the transitional zone. 4. Low ADC values on DWI are associated with higher-grade malignancy.

PCa and pathologic Gleason grading system Prostate MRI Sequences - T2 - DWI/ADC - Dynamic contrast enhancement (DCE) - MR Spectroscopy MP-MRI appearance of PCa and mimics - PCa - PIN -Prostatitis ESUR-PIRADS interpretation scheme -T2 -DWI/ADC -DCE -MR Spectroscopy -Composite PIRADS Score Rad-Path Case illustrations

http://abstract.rsna.org/uploads/2014/14004408/14004408_6ip5.pdf

Cool, D, Gibson, E, Gaed, M, Gomez, J, Moussa, M, Ward, A, Fenster, A, Pautler, S, Chin, J, Izawa, J, Baumann, G, Romagnoli, C, Prostate Imaging Reporting and Data System (PIRADS) for Multiparameteric Prostate MRI (MP-MRI) Interpretation: Radiologic-Pathologic Correlation .  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14004408.html