Christy Blaire Pomeranz MD, Presenter: Nothing to Disclose

Sharon Meei Ay Ngu MBChB, Abstract Co-Author: Nothing to Disclose

Richard Kinh Gian Do MD, PhD, Abstract Co-Author: Nothing to Disclose

1. Review the new pathologic subtypes of hepatocellular adenomas and their genotypic and phenotypic differences. 2. Review distinguishing features and imaging characteristics of different adenoma subtypes on contrast enhanced MRI.  

Hepatocellular adenomas (HCA) are benign liver tumors, which may display a host of clinical consequences including malignant transformation and bleeding. The Bordeaux group has recently shown that they are, pathologically, a heterogeneous group of tumors which can be sub-classified into four different subtypes: HNF1α mutation HCA (35-40%), β-catenin positive HCA (10-15%), inflammatory HCA (40-50%), and unclassified HCA (5-10%). There are increasing reports of differences in imaging characteristics of HCA by subtype on contrast enhanced MRI. Radiologists will play an important role in clinical management if they are able to differentiate between different HCA subtypes on imaging since the subset of β-catenin positive HCA have an increased risked of malignant transformation and inflammatory HCA have an increased risk of bleeding. The emerging MR imaging characteritics of HCA will be illustrated and compared to other hypervascular liver tumors.  

http://abstract.rsna.org/uploads/2014/14004283/14004283_gtgi.pdf

Pomeranz, C, Ngu, S, Do, R, Subtype Classification of Hepatocellular Adenomas and Their Distinguishing, Imaging Characteristics on MRI.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14004283.html