Colin Yi BA, Presenter: Nothing to Disclose

Colin Wu, Abstract Co-Author: Nothing to Disclose

Michael Tee BS, Abstract Co-Author: Nothing to Disclose

Chia-Ying Liu, Abstract Co-Author: Nothing to Disclose

Gustavo Volpe MD, Abstract Co-Author: Nothing to Disclose

Martin R. Prince MD, PhD, Abstract Co-Author: Patent agreement, General Electric Company Patent agreement, Hitachi, Ltd Patent agreement, Siemens AG Patent agreement, Toshiba Corporation Patent agreement, Koninklijke Philips NV Patent agreement, Nemoto Kyorindo Co, Ltd Patent agreement, Bayer AG Speaker Honorarium, Bayer AG Patent agreement, Lantheus Medical Imaging, Inc Patent agreement, Bracco Group Speaker Honorarium, Bracco Group Patent agreement, Covidien AG Patent agreement, Topspins, Inc Stockholder, Topspins, Inc

Gregory Hundley MD, Abstract Co-Author: Research Grant, Astellas Group Speakers Bureau, Bracco Group Stockholder, Prova Images

Antoinette Susan Gomes MD, Abstract Co-Author: Stockholder, St. Jude Medical, Inc

Rob J. Van Der Geest MS, Abstract Co-Author: Consultant, Medis Medical Imaging Systems, Inc

Susan Heckbert, Abstract Co-Author: Nothing to Disclose

Joao A. C. Lima MD, Abstract Co-Author: Research Grant, Toshiba Corporation

David A. Bluemke MD, PhD, Abstract Co-Author: Research support, Siemens AG

Risk scores for cardiovascular disease (CVD) integrate multiple CVD risk factors in order to identify individuals likely to experience a CVD outcome, such as myocardial infarction or death. Risk score models such as Framingham incorporate factors that may also increase myocardial fibrosis, such as age, smoking, diabetes and blood pressure. We hypothesized that individuals at higher risk for CVD may also have greater indices of myocardial fibrosis as measured by cardiac magnetic resonance (CMR).  

Study subjects in the Multiethnic Study of Atherosclerosis (MESA) free from clinical cardiovascular disease at enrollment underwent CMR imaging at 1.5T at six centers. T1 times were determined a) before (native T1), b) 12 min and c) 25 min after gadolinium administration (0.15 mmol/kg) using a modified Look-Locker pulse sequence. The correlations between the different CMR measures and extracellular volume fraction (ECV) and 14 established different cardiovascular risk scores were determined. The Generalized Additive Model (GAM) was employed to evaluate the adequacy of the linear relationships.

1208 subjects (men, 50.8%) ages 55-94 years old were evaluated. CVD risk scores were significantly different for men and women (p < 0.001). Of 14 cardiovascular risk scores, 10 (71%)) were significantly associated with 25 minute post-contrast T1 time among men (p < 0.05). In addition, 7/14 (50%) of risk scores were significantly associated with native T1 time among men. As for women, only ECV showed significant correlations with 2/14 (14%) risk scores. Reynolds and MESA risk scores showed the most consistent agreement with CMR measures. The new AHA/ASCVD risk score showed no relationship to CMR indices of myocardial fibrosis.  

Asymptomatic men with greater CVD risk by contemporary risk scores had greater CMR indices of myocardial fibrosis. These results support the use of post-gadolinium T1 time as an index of myocardial fibrosis.

Future studies relating T1 time or ECV measurements to cardiovascular events will help to further refine the role of T1 mapping by CMR in asymptomatic individuals.

Yi, C, Wu, C, Tee, M, Liu, C, Volpe, G, Prince, M, Hundley, G, Gomes, A, Van Der Geest, R, Heckbert, S, Lima, J, Bluemke, D, The Association between Cardiovascular Risk and CMR Measures of Fibrosis: The Multi-Ethnic Study of Atherosclerosis (MESA).  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14004056.html