Ameya Jagadish Baxi MBBS, DMRD, Presenter: Nothing to Disclose

Carlos S. Restrepo MD, Abstract Co-Author: Nothing to Disclose

Michael James McCarthy MD, Abstract Co-Author: Nothing to Disclose

Daniel Vargas MD, Abstract Co-Author: Nothing to Disclose

Daniel Ocazionez MD, Abstract Co-Author: Nothing to Disclose

Horacio Murillo MD, PhD, Abstract Co-Author: Nothing to Disclose

Rashmi S. Katre, Abstract Co-Author: Nothing to Disclose

1. To study patterns of myocardial involvement in hypertrophy cardiomyopathy (HCM) 2. To review genetics, pathophysiology and imaging findings in HCM  

HCM is a genetic cardiac disease caused by dominant mutations in sarcomere genes with remarkable heterogeneity. It causes diffuse or segmental left ventricular hypertrophy with stiffened walls and abnormal valve function. Patients can be asymptomatic or develop symptoms such as chest pain, shortness of breath, fainting, palpitation and sudden death. Noninvasive imaging plays pivotal role in detecting HCM and understanding its pathophysiology. Echocardiography is the most widely used modality for initial evaluation. But is limited by poor window and interobserver variation. MDCT offers high-quality multiplanar reconstructions and be used in patients with pacemakers. Radiation exposure and use of iodinated contrast are its short comings. It cannot depict areas of fibrosis. MRI offers multiplanar imaging, gradient analysis and assess distribution of LV hypertrophy and gives unparallel tissue characterization thus accurately depicting areas of fibrosis manifesting as delayed enhancement. It is the imaging modality of choice for patients considered for alcohol ablation.Radiologists should be familiar with the imaging appearances of HCM and understand clinical significance.  

http://abstract.rsna.org/uploads/2014/14003778/14003778_9otp.pdf

Baxi, A, Restrepo, C, McCarthy, M, Vargas, D, Ocazionez, D, Murillo, H, Katre, R, Hypertrophic Cardiomyopathy from A to Z: Genetics, Pathophysiology, Imaging and Management.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14003778.html