Ross Holwerda MD, Presenter: Nothing to Disclose

Christopher Walker MD, Abstract Co-Author: Author, Amirsys, Inc Author, Reed Elsevier

Melissa L. Rosado De Christenson MD, Abstract Co-Author: Author, Thieme Medical Publishers, Inc Author, Amirsys, Inc Author, American Registry of Pathology Author, Oxford University Press

Santiago Martinez-Jimenez MD, Abstract Co-Author: Author, Amirsys, Inc

Jeffrey Russell Kunin MD, Abstract Co-Author: Investigator, Oncimmune LLC

Paul P. Pettavel MD, Abstract Co-Author: Nothing to Disclose

1. Metastases from hepatobiliary and pancreatic neoplasms often follow predictable patterns of spread in the thorax. 2. Knowledge of classic and atypical imaging appearances allows the radiologist to tailor his/her search pattern based on the specific malignancy, better evaluate disease progression, and avoid misdiagnosis of concurrent benign conditions.

1. Thoracic metastases from hepatobiliary and pancreatic neoplasms. 2. Typical and atypical patterns of metastatic spread and role of biomarkers in diagnosis and follow-up (e.g. AFP, CA19-9, CgA) - Hepatocelluar carcinoma - intracardiac tumor thrombus/tumor emboli, lymphadenopathy, hematogenous dissemination, diaphragm invasion - Hepatic angiosarcoma - nodules with surrounding ground glass opacity (CT halo sign) - Pancreatic adenocarcinoma - pulmonary nodules with or without cavitation, tumor emboli, consolidation, ground-glass opacities (lepidic tumor growth), and CT halo sign - Pancreatic neuroendocrine tumor - hypervascular metastases - Cholangiocarcinoma/gallbladder cancer - cavitary and noncavitary pulmonary nodules 3. Incidence of intrathoracic complications (e.g. pulmonary embolism incidence higher in hepatobiliary and pancreatic malignancies compared to other malignancies).  

http://abstract.rsna.org/uploads/2014/14003764/14003764_3jkp.pdf

Holwerda, R, Walker, C, Rosado De Christenson, M, Martinez-Jimenez, S, Kunin, J, Pettavel, P, Thoracic Manifestations of Hepatobiliary and Pancreatic Malignancies: How Do They Differ from Other Tumors?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14003764.html