Xiang Yuan Yin, Abstract Co-Author: Nothing to Disclose

Shi Jun Qiu MD, Presenter: Nothing to Disclose

Zhen Yin Liu, Abstract Co-Author: Nothing to Disclose

Hong Zhuo Wang, Abstract Co-Author: Nothing to Disclose

Wei Feng Xiong, Abstract Co-Author: Nothing to Disclose

Shan Shan Li, Abstract Co-Author: Nothing to Disclose

Jie An, Abstract Co-Author: Nothing to Disclose

Dong Lin Wu, Abstract Co-Author: Nothing to Disclose

Our study aimed to examine extratemporal abnormalities of cerebral parenchyma in young adult TLE patients , using DTI.

The study comprised 20 adults with unilateral TLE and 20 controls. We calculated fractional anisotropy (FA), apparent diffusion coefficient (ADC), parallel eigenvalue (λ∥) and perpendicular eigenvalue (λ⊥) in the ROIs using a 3-T MRI scanner. ROIs included: anterior/posterior limb of the internal capsule (AIC/PIC), external capsule (EC), head of caudate nucleus (HCN), lenticular nucleus (LN), thalamus (TL) and genu/ body / splenium of the corpus callosum (GCC/BCC/SCC).

Compared to controls, TLE patients showed: lower FA in all ROIs; higher ADC in bilateral ECs, HCNs, TLs and BCC; lower λ∥ in ipsilateral LN and bilateral AICs, TL and GCC; higher λ⊥ in all ROIs except the bilateral PICs. In TLE patients, the ipsilateral TL had decreased FA compared with the contralateral TL. Pearson correlation analysisa revealed a negative correlation between ADC of GCC and the epilepsy onset age, λ∥ of ipsilateral PIC and the epilepsy onset age, λ⊥ of contralateral AIC and the duration of epilepsy, respectively; and a positive correlation between ADC of GCC and the duration of epilepsy, λ⊥ of GCC and the duration of epilepsy, respectively.

The study revealed bilateral extratemporal abnormalities in young adult TLE patients compared with controls; and TLE patients with younger onset age or longer duration of epilepsy may have more serious extratemporal changes

fMRI

Yin, X, Qiu, S, Liu, Z, Wang, H, Xiong, W, Li, S, An, J, Wu, D, Extratemporal Abnormalities of Brain Parenchyma in Young Adults with Temporal Lobe Epilepsy: A Diffusion Tensor Imaging Study.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14003755.html