Zuohua Tang MS, MD, Presenter: Nothing to Disclose

Jie Wang, Abstract Co-Author: Nothing to Disclose

Lingjie Wu MD, Abstract Co-Author: Nothing to Disclose

To evaluate the value of perfusion CT (CTP), microvessel density (MVD), and vascular endothelial growth factor (VEGF) in the differentiation of malignant from benign head and neck neoplasms (HNNs).

Forty-one HNNs proven by pathology underwent CTP, MVD, and VEGF analysis. All lesions were divided into three groups: Group A, benign hypovascular lesions; Group B, benign hypervascular lesions; and Group C, malignant lesions. A time density curve (TDC) and CTP parameters (MIP, BV, BF, MTT, CP) were analysed. The relationship between the perfusion measurements and MVD/VEGF was assessed by Pearson correlation.

 The TDCs could be classified into three types. TDC of type I was mainly found in Group A, and type II was found in Groups B and C. MIP, BF, and BV were all significantly higher in Groups B and C compared to Group A (all P < 0.01). Pearson correlation showed a positive correlation between the MVD and MIP, BV, and VEGF, respectively (all P<0.05). The VEGF expression in Group C was significantly higher than that in Groups A and B (all P<0.05). 

The MIP and BV of CTP correlate positively with MVD and may reflect angiogenesis of HNNs. CTP combined with VEGF could be beneficial by allowing differentiation of malignant from benign HNNs.

CTP may reflect angiogenesis of head and neck neoplasms (HNNs) and is helpful in the differentiation of malignant from benign HNNs and is recommended in the initial evaluation of HNNs.

Tang, Z, Wang, J, Wu, L, Head and Neck Neoplasms: Correlation of CT Perfusion Imaging with Microvessel Density and Cascular Endothelial Growth Factor .  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14003717.html