Axel Van Der Gucht, Presenter: Nothing to Disclose

Antoine Verger, Abstract Co-Author: Nothing to Disclose

Yalcin Yagdigul, Abstract Co-Author: Nothing to Disclose

Sylvain Poussier, Abstract Co-Author: Nothing to Disclose

Laure Joly, Abstract Co-Author: Nothing to Disclose

Ghassan Watfa, Abstract Co-Author: Nothing to Disclose

Athanase Benetos, Abstract Co-Author: Nothing to Disclose

Gilles Karcher, Abstract Co-Author: Nothing to Disclose

Pierre-Yves Marie MD, PhD, Abstract Co-Author: Nothing to Disclose

18F-FDG PET can be used to aid in the diagnosis of AD and clarify the diagnosis and prognosis of patients with mild cognitive impairment (MCI). The goal of this study was to compare the results of a quantitative analysis of FDG-PET brain images to a standard visual analysis with regards to the detection of MCI-like hypometabolic patterns in elderly patients with hypertension and subjective, isolated memory complaints.

FDG-PET brain was performed in 71 patients (mean age: 76.4 ± 5.1 years, female: 53.5%). Images were analyzed for the presence of an MCI-like hypometabolic pattern using an SVA by 2 physicians and a voxel-based quantitative analysis (Statistical Parametric Mapping) that compared each patient's images to normal reference samples from 19 elderly individuals obtained using the same PET camera. The reliability of these analyses was evaluated according to neuropsychological assessment results, including the Grober and Buschke Free and Cued Selective Reminding Test, and a combined analysis by a neuropsychologist.

An MCI-like hypometabolic pattern was documented in 8 patients (11%) by SVA and 7 patients (10%) by quantitative SPM analysis; however, only 3 of these patients were selected by both methods. The group characteristics of the 7 patients identified by the quantitative method were consistent with the MCI-pattern, which included a higher rate of abnormal GB-FCSRT in Free Recall (57% vs. 9%, p<0.05) or in Total Recall (29% vs. 8%, p<0.05) when compared with other patients. In contrast, the group identified by SVA did not exhibit these characteristics.

A combined visual and quantitative analysis improves the diagnostic accuracy to detect an MCI-like hypometabolic pattern in elderly patients with hypertension and subjective, isolated memory complaints.

A combined visual and quantitative analysis improves the diagnostic accuracy to detect an MCI-like hypometabolic pattern in elderly patients with hypertension and subjective, isolated memory complaints

Van Der Gucht, A, Verger, A, Yagdigul, Y, Poussier, S, Joly, L, Watfa, G, Benetos, A, Karcher, G, Marie, P, Complementarity of Visual and Voxel-based FDG-PET Analysis to Detect MCI-like Hypometabolic Patterns in Elderly Patients with Hypertension and Isolated Memory Complaints.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14003192.html