Maura Micco MD, Presenter: Nothing to Disclose

Hebert Alberto Vargas MD, Abstract Co-Author: Nothing to Disclose

Seong Im Hong, Abstract Co-Author: Nothing to Disclose

Debra A. Goldman MS, Abstract Co-Author: Nothing to Disclose

Fanny Dao, Abstract Co-Author: Nothing to Disclose

Britta Weigelt, Abstract Co-Author: Nothing to Disclose

Robert Soslow, Abstract Co-Author: Nothing to Disclose

Hedvig Hricak MD, PhD, Abstract Co-Author: Nothing to Disclose

Douglas Levine, Abstract Co-Author: Nothing to Disclose

Evis Sala MD, PhD, Abstract Co-Author: Nothing to Disclose

Transcriptomic analyses of high-grade serous ovarian cancer (HGSOC) by The Cancer Genome Atlas (TCGA) Research Network revealed four prognostically-relevant “Classification of Ovarian Cancer” (CLOVAR) subtypes of HGSOC. We aimed to investigate associations between radiophenotypic features observed on computed tomography (CT), CLOVAR gene signatures and survival in women with HGSOC.

Retrospective analysis of CT images obtained before cytoreductive surgery in 46 women with HGSOC, whose tumors were subjected to molecular analyses by TCGA. Two readers independently evaluated all CTs. Fisher’s exact test was used to examine the relationship between imaging features and CLOVAR subtypes (CLOVAR “differentiated,” “immunoreactive,” “mesenchymal” and “proliferative”). Inter-reader agreement was assessed using Cohen’s kappa (k) statistics. Kaplan-Meier survival analyses were performed.

The presence of mesenteric infiltration and diffuse peritoneal involvement by tumor on CT were significantly associated with CLOVAR subtype (p=0.002-0.004 for reader 1 [R1] and p=0.006-0.012 for R2). Inter-reader agreement in evaluating these two features on imaging was substantial to almost perfect (k=0.79-0.91). Mesenteric infiltration on imaging was associated with CLOVAR mesenchymal subtype. Patients with mesenteric infiltration had shorter median progression-free survival than patients without mesenteric involvement (14.75 months vs 25.57 months according to both readers; p=0.019/0.015 for R1/R2) and overall survival (49.04 vs 58.18 months; p=0.010 [R1] and 50.03 vs 59.05 months; p=0.011 [R2]) . No other imaging features were significantly associated with CLOVAR subtype or survival.

Specific CT features are associated with the HGSOC CLOVAR subtypes and may have potential as prognostic biomarkers in patients with HGSOC.

Our study highlights potentially clinically useful associations between prognostically relevant genomic signatures and specific imaging phenotypes observed on CT in patients with HGSOC.

Micco, M, Vargas, H, Hong, S, Goldman, D, Dao, F, Weigelt, B, Soslow, R, Hricak, H, Levine, D, Sala, E, Association between Radiophenotypic Computed Tomography Features and Prognostically Relevant Gene Signatures in Women with High-grade Serous Ovarian Cancer.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002764.html