youping xiao, Presenter: Nothing to Disclose

Yunbin Chen MD, Abstract Co-Author: Nothing to Disclose

Jianji Pan, Abstract Co-Author: Nothing to Disclose

Zhuangzhen He, Abstract Co-Author: Nothing to Disclose

Ying N. Chen PhD, Abstract Co-Author: Nothing to Disclose

Wang Ren, Abstract Co-Author: Nothing to Disclose

Xiangyi Liu BS, Abstract Co-Author: Nothing to Disclose

Linfeng Cai BS, Abstract Co-Author: Nothing to Disclose

Weibo Chen PhD, Abstract Co-Author: Nothing to Disclose

Dechun Zheng MS, Abstract Co-Author: Nothing to Disclose

To evaluate the intravoxel incoherent motion magnetic resonance imaging(IVIM-MRI) derived parameters in early predicting the responsiveness to neoadjuvant chemotherapy(NAC) for locally advanced nasopharyngeal carcinoma(NPC).

From August 2012 to May 2013, IVIM-MRI with 14 b factors (0~1000s/mm2) performed on a 3.0 T MR imaging system(Achieva 3.0T, Philips Healthcare, Best, The Netherlands) was conducted on 56 consecutive patients with locally advanced NPC at the pretreatment and the 3rd day(day3), the 21st day(day21) after chemotherapy initiation. At the end of NAC, patients were classified into responders and non-responders according to the Response Evaluation Criteria in Solid Tumors (RECIST) based on MR measurement. The IVIM derived parameters(D, pure diffusion coefficient; f, perfusion fraction; and D*, pseudo-diffusion coefficient) were calculated twicely by two experienced radiologists separately on an in-house software of IDL6.3(Boulder, Chicago, USA) based on a bi-exponential algorithm model of IVIM theory. Their corresponding changes (Δparameter(dayX)(X=3 or 21)) were then compared between two response groups with Mann-Whitney U test. Interclass coefficient of variation(ICC) was applied to test the intra- and inter-observer measurement reproducibility. Statistical analyses were performed on SPSS 18.0. P<0.05 was considered significant.  

Finally, 48 patients(Stage III, 19 and Stage IV, 29) were recruited into the present study. 37 patients were categorized as responders after NAC. The intra- and inter-observer ICCs of D, D* and f were excellent ranging from 0.949 to 0.978 and the coefficient of variances were small ranging from1.92%~26.01%. Significantly higher D and lower D* were observed at both day3(P<0.05) and day21(P<0.001) than pre-treatment. While no significant difference was presented on parameter f between them(P>0.05). By comparing to non-responders, responders presented notably larger ΔD3, ΔD21, ΔD*3, ΔD*21 and Δf21(P<0.05), while no significant difference was shown on Δf3(P>0.1).

Locally advanced NPC presents characteristic changes of IVIM derived parameters after NAC, D and D* are more feasible than f in early predicting the chemotherapeutic response for NPC. 

IVIM paramters has a significant clinical application values and may help to optimize the chemotherapeutic regimens at the early stage of neoadjuvant chemotherapy for advanced nasopharyngeal carcinoma.

xiao, y, Chen, Y, Pan, J, He, Z, Chen, Y, Ren, W, Liu, X, Cai, L, Chen, W, Zheng, D, Intravoxel Incoherent Motion Magnetic Resonance Imaging Derived Parameters in Early Predicting Responsiveness of Neoadjuvant Chemotherapy for Locally Advanced Nasopharyngeal Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002717.html