Amish Lakhani MBBS, MA, Presenter: Nothing to Disclose

Anwar Roshanali Padhani MD, Abstract Co-Author: Advisory Board, Acuitas Medical Ltd Advisory Board, Siemens AG Speakers Bureau, Siemens AG Researcher, Siemens AG Speakers Bureau, Johnson & Johnson

Andrew Gogbashian MD, FRCR, Abstract Co-Author: Nothing to Disclose

Roberto Alonzi MD, Abstract Co-Author: Nothing to Disclose

Nicola Anyamane MD, FRCR, Abstract Co-Author: Nothing to Disclose

1) Modern imaging techniques such as Choline/NaF PET-CT and whole body MRI can detect bone metastases with increased sensitivity before bone scans; early detection and therapy has been shown to result in survival benefits. 2) Functional imaging methods are able to positively assess therapy response compared to bone scans which can only identify tumor progression; these more accurate assessments of therapy response aids the rational use of targeted therapy for metastatic disease.  

1) Overview of the current methods and challenges of assessing the presence and response of metastatic prostate cancer to bone. 2) Review the relative performance of planar bone scans compared to modern techniques for detecting bone disease using published meta-analyses. 3) Discuss DW-MRI as a new viable sequence for metastases detection, outlining its added value to standard sequences in whole body (WB) examinations. 4) Provide examples of how WB-DWI overcomes the limitations of morphologic sequences for disease detection and response assessment to standard and targeted therapies. 5) Illustrate the indications for WB-MRI imaging in routine clinical practice from our database of >2500 WB-MRI examinations, with supportive literature data. 6) Teaching points and future directions. 

http://abstract.rsna.org/uploads/2014/14002681/14002681_c286.pdf

Lakhani, A, Padhani, A, Gogbashian, A, Alonzi, R, Anyamane, N, Modern Imaging Techniques for Metastatic Prostate Cancer: Is the Bone Scan Dead?.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002681.html