Jisang Park MD, Presenter: Nothing to Disclose

Hyun-Sook Hong MD, PhD, Abstract Co-Author: Nothing to Disclose

Chul-Hee Kim, Abstract Co-Author: Nothing to Disclose

Kee Hyun Chang MD, PhD, Abstract Co-Author: Nothing to Disclose

Eun Hye Lee MD, Abstract Co-Author: Nothing to Disclose

Sun Hye Jeong MD, Abstract Co-Author: Nothing to Disclose

Aleum Lee MD, Abstract Co-Author: Nothing to Disclose

Heon Lee, Abstract Co-Author: Nothing to Disclose

To evaluate the diagnostic value of acoustic structure quantification(ASQ) for the diagnosis of diffuse thyroid disease (DTD). To identify cut-off levels of ASQ values in the differentiation of DTD and normal thyroid. To identify any difference in the subgroups of DTD between thyroid function and ASQ values.

ASQ values were retrospectively analyzed from 439 lobes of 234 patients. The DTD group was divided into five subgroups (Hashimoto’s thyroiditis, painless thyroiditis, subacute thyroiditis, postpartum thyroiditis, and Grave’s disease). ASQ values were used to assess the echogenecity of thyroid. ASQ results included both qualitative visual results as well as quantitative results. The results are shown as occurrence in the C2m histogram(modified chi-squared distribution) with the mode, average, ratio, blue-mode, and blue-average. ROC curve analysis was performed to assess the diagnostic value of ASQ values for DTD, and cut-off values were obtained for the differentiation of DTD and normal thyroid gland function. The trends between thyroid function and ASQ values were evaluated. Concordance correlation coefficients of ASQ values were obtained.

The mean ASQ values in patients with DTD were significantly greater than normal thyroid(p=.000). The areas under the ROC curves for the ratio, average, blue-average, mode, and blue-mode were 0.93, 0.91, 0.90, 0.87, and 0.87, respectively. The cut-off values of the ratio, average, and blue-average in the DTD diagnosis were >0.27, >116.7, and >130.7, respectively. The sensitivity were 84.0, 85.3, and 79.1% and specificity were 96.6, 83.0, and 93.2%(ratio, average, and blue-average, respectively). A significant difference in ASQ values was found according to the hormonal status(p=.000). Trend analysis showed a quadratic trend between the hormonal status and ASQ values. The concordance correlation coefficient of obtaining ASQ values was very good.

ASQ values can provide objective and quantitative non-invasive analysis of thyroid echogenecity. ASQ value determination can be an objective guide to differentiate DTD from normal and has good diagnostic value for clinical application in the diagnosis and monitoring of DTD.

(dealing with ultrasonography) “ASQ can provide objective and quantitative analysis of thyroid echogenecity. This exam is recommended for diagnosis and monitoring of diffuse thyroid disease.”

Park, J, Hong, H, Kim, C, Chang, K, Lee, E, Jeong, S, Lee, A, Lee, H, The Usefulness of Acoustic Structure Quantification Values in the Evaluation of Diffuse Thyroid Disease.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002551.html