Venkata S. Katabathina MD, Presenter: Nothing to Disclose

Farhan S. Amanullah MD, Abstract Co-Author: Nothing to Disclose

Srinivasa R. Prasad MD, Abstract Co-Author: Nothing to Disclose

Christine O. Menias MD, Abstract Co-Author: Nothing to Disclose

Philip T. Valente MD, Abstract Co-Author: Nothing to Disclose

Kedar Nath Chintapalli MD, Abstract Co-Author: Nothing to Disclose

Review recent advances regarding the origin and pathogenesis of extrauterine pelvic serous carcinomas (fallopian tube, peritoneum & ovary) Discuss molecular and cytogenetic abnormalities associated with these malignancies & their management implications Describe cross-sectional imaging findings & role of different imaging techniques in diagnosis & management  

Introduction Taxonomy: Ovarian serous carcinoma, primary fallopian tube carcinoma & primary peritoneal carcinoma Central role of fallopian tube epithelium in pathogenesis Molecular abnormalities: TP53, BRCA 1 & 2, KRAS & BRAF mutations Pathologic Findings Cross-sectional imaging findings & role of imaging Clinical implications Novel therapeutic targets Conclusion Ovarian serous, primary peritoneal & fallopian tube carcinomas are deadliest gynecologic malignancies. Ongoing research suggests that fallopian tubal epithelium is the origin of these cancers and multiple genetic mutations have been identified. New management methods such as prophylactic salpingectomy in prevention of ovarian epithelial cancers have been attempted. Novel, targeted drugs are being tested; serums markers helpful in screening, prognostification, and treatment follow-up have been identified. Cross-sectional imaging techniques help in diagnosis, surveillance & testing efficacy of novel drugs.  

http://abstract.rsna.org/uploads/2014/14002472/14002472_4qo9.pdf

Katabathina, V, Amanullah, F, Prasad, S, Menias, C, Valente, P, Chintapalli, K, Current Update on Extrauterine Pelvic Serous Carcinomas: Implications for Diagnosis and Management.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002472.html