Ah Young Park MD, Presenter: Nothing to Disclose

Eun Ju Son MD, PhD, Abstract Co-Author: Nothing to Disclose

Jeong-Ah Kim MD, PhD, Abstract Co-Author: Nothing to Disclose

Ji Hyun Youk MD, Abstract Co-Author: Nothing to Disclose

Yun Joo Park MD, PhD, Abstract Co-Author: Nothing to Disclose

Cheong Soo Park, Abstract Co-Author: Nothing to Disclose

To evaluate the association of the BRAFV600E mutation with sonographic features and clinicopathologic parameters in a large-scale study population with conventional papillary thyroid carcinoma (PTC).

This was an institutional review board–approved retrospective study with waiver of informed consent. Between January and July 2010, 688 patients who underwent thyroidectomy for conventional PTC were enrolled. The sonographic features, clinicopathologic parameters and the presence of BRAFV600E mutation were retrospectively reviewed. The rate of BRAFV600E mutation was calculated. The sonographic features and clinicopathologic parameters were compared between the BRAF-positive PTC and BRAF-negative PTC. The association of sonographic features with BRAFV600E mutation was evaluated in papillary thyroid microcarcinoma (PTMC group) and PTC larger than 10mm (PTC>10mm group), respectively.

The BRAFV600E mutation was detected in 69.2% (476 of 688). The sonographic features were not significantly different between the BRAF-positive and negative PTC, also in both PTMC and PTC>10mm groups, respectively. The BRAFV600E mutation was associated with male gender, large tumor size, extrathyroidal extension, central and lateral lymph node metastasis, and advanced tumor stage (P=.028 for the patients’ sex, P<.0001 for tumor size, extrathyroidal extension, lymph node metastasis and tumor stage).

The BRAFV600E mutation was not associated with sonographic features, regardless of tumor size in PTC patients, but was associated with poor clinicopathologic parameters.

Therefore, preoperative BRAFV600E mutation analysis for thyroid nodule with suspicious sonographic features could be recommendable for risk stratification and initial surgical approach of PTC.

Park, A, Son, E, Kim, J, Youk, J, Park, Y, Park, C, The Association of the BRAFV600E Mutation with Sonographic Features and Clinicopathologic Parameters in a Large-scale Study Population with Conventional Papillary Thyroid Carcinoma.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002323.html