Amish Lakhani MBBS, MA, Presenter: Nothing to Disclose

Anwar Roshanali Padhani MD, Abstract Co-Author: Advisory Board, Acuitas Medical Ltd Advisory Board, Siemens AG Speakers Bureau, Siemens AG Researcher, Siemens AG Speakers Bureau, Johnson & Johnson

Andrew Gogbashian MD, FRCR, Abstract Co-Author: Nothing to Disclose

Tina Mistry MBBS, FRCR, Abstract Co-Author: Nothing to Disclose

Ashik Amlani, Abstract Co-Author: Nothing to Disclose

Subhadip Ghosh-Ray MBBS, Abstract Co-Author: Nothing to Disclose

(1) DW-MRI is excellent at showing the distribution of bone marrow in health and disease; reflecting the cellular status of the bone marrow that correlates with histologic cellularity measurements. (2) There are non-linear relationships between bone marrow cellularity and DWI parameters (high b-value SI & ADC) with cellularity & fat have dominant competing effects. (3) Bone marrow assessments on DW-MRI should be done in conjunction with morphologic and quantitative fat sequences particularly for the assessment of changes in response to therapy.  

(1) Brief overview whole body DWI (WB-DWI) as a method suited for whole body applications including technique, post-processing and display methods. (2) Review of normal bone marrow structure, its variability with age and appearance on WB-DWI. (3) To demonstrate the non-linear relationships between diffusion imaging parameters (high b-value SI & ADC) and bone marrow fat fraction. (4) Review with case illustrations, the causes of bone marrow hypocellularity and hypercellularity, including the effects of chemotherapy, hormonal treatments and bone marrow stimulating factors. (5) Summary, teaching points and future directions.  

http://abstract.rsna.org/uploads/2014/14002072/14002072_pb36.pdf

Lakhani, A, Padhani, A, Gogbashian, A, Mistry, T, Amlani, A, Ghosh-Ray, S, Bone Marrow Assessments with Diffusion Weighted Imaging (DWI).  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14002072.html