Tsutomu Tamada MD, PhD, Presenter: Nothing to Disclose

Katsuyoshi Ito MD, Abstract Co-Author: Nothing to Disclose

Akira Yamamoto MD, Abstract Co-Author: Nothing to Disclose

Atsushi Higaki MD, Abstract Co-Author: Nothing to Disclose

Akihiko Kanki MD, Abstract Co-Author: Nothing to Disclose

Daigo Tanimoto MD, Abstract Co-Author: Nothing to Disclose

Minoru Hayashida MD, Abstract Co-Author: Nothing to Disclose

To understand the pharmacologic characteristics of Gd-EOB-DTPA (EOB) To demonstrate the optimal protocol of EOB-enhanced MR imaging for the correct diagnosis of hepatocellular nodules in the chronic hepatitis or liver cirrhosis To illustrate the pitfalls of EOB-enhanced MR imaging for the detection of hepatocellular nodule in patients with chronic liver disease  

Pharmacologic characteristics of EOB - Pharmacokinetics - Comparison with Gd-DTPA - EOB-related acute transient dyspnea - Low tissue deposition of gadolinium in EOB Optimization of EOB-enhanced MR imaging protocol - Vascular phase imaging:      Arterial phase imaging; injection rate, imaging timing, muitiphase acquisition      Interpretation on equilibrium phase - Hepatobiliary phase (HP) imaging: timing of acquisition, optimal flip angle, effect of hepatic function - Idea for shorten examination time - Proper protocol for the detection of hepatocellular nodules Pitfalls - Typical EOB-enhanced MR imaging findings reflecting multi-step hepatocarcinogenesis - Early enhancing lesions showing hypointensity on HP mimicking hypervascular HCC - Nodules showing high signal intensity on HP - Peripheral low intensity sign (target sign) on HP - Periportal high intensity sign on HP  

http://abstract.rsna.org/uploads/2014/14001984/14001984_8xky.pdf

Tamada, T, Ito, K, Yamamoto, A, Higaki, A, Kanki, A, Tanimoto, D, Hayashida, M, Understanding Gd-EOB-DTPA-enhanced MR Imaging of the Liver: Practical Approaches and Pitfalls.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14001984.html