Ammar Ahmed Chaudhry MD, Presenter: Nothing to Disclose

Maryam Gul, Abstract Co-Author: Nothing to Disclose

Abbas Ahmed Chaudhry BSc, Abstract Co-Author: Nothing to Disclose

Mubashir Sheikh, Abstract Co-Author: Nothing to Disclose

Jawed Akhter Mallick MBBS, Abstract Co-Author: Nothing to Disclose

Jared Dunkin MD, Abstract Co-Author: Nothing to Disclose

1. Pictorial review of CNS anatomy highlight areas involved in paraneoplastic syndromes.   2. Case based review highlighting common and uncommon causes of paraneoplastic syndrome. 3. Discuss differential diagnoses (physiologic process, congenital, infection, inflammation, trauma, vascular and/or malignancy) that can mimic imaging findings.

Content: Multiple presentations of paraneoplastic syndrome will be reviewed involving the brain and spine. We will discuss mimics that may result from neoplasm (lymphoma, leukemia,etc), infection (HSV, Lyme, etc), inflammation (MS, ADEM, Lupus), etc with an emphasis on key findings (on CT, MRI, PET-MRI) differentiating these entities.   Summary: Paraneoplastic syndrome is not an uncommon cause of encephalitis. Knowledge of its clinical presentation, pathophysiology and immunology is essential in making the diagnosis. Although the differential diagnosis is broad, it can be narrowed utilizing age, clinical features, imaging characteristics (e.g. Location, enhancement pattern, PET-MRI findings, etc) and pathology correlation. By the conclusion of this presentation, the viewer should have a better understanding of paraneoplastic syndrome and associated imaging findings, and should be able to aid in the workup, guide any potential biopsy/tissue sampling and imaging follow-up.  

http://abstract.rsna.org/uploads/2014/14001953/14001953_lcyw.pdf

Chaudhry, A, Gul, M, Chaudhry, A, Sheikh, M, Mallick, J, Dunkin, J, Paraneoplastic Syndrome and Mimics: What the Radiology and Clinicians Need to Know.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14001953.html