Yong-An Chung MD, PhD, Presenter: Nothing to Disclose

So Hwa Yoon, Abstract Co-Author: Nothing to Disclose

In Uk Song, Abstract Co-Author: Nothing to Disclose

Jin Kyung Oh MD, Abstract Co-Author: Nothing to Disclose

Kijun Kim, Abstract Co-Author: Nothing to Disclose

Decreased myocardial uptake of I-123 metaiodobenzylguanidine (MIBG) is important finding for diagnosis of Parkinson’s disease. This retrospective study compared I-123 MIBG SPECT and planar imaging with regard to their diagnostic yield for Parkinson’s disease.

Clinically diagnosed Parkinson’ disease patients who also had decreased striatal uptake on FP-CIT PET/CT were enrolled between November 2011 and May 2013. They had undergone cardiac MIBG planar scintigraphy and SPECT. Myocardial I-123 MIBG uptake was interpreted separately on planar and SPECT/CT images. Heart to mediastinum (H/M) and lung to mediastinum (L/M) ratio was also evaluated.

Eighty three patients were included for image analysis. 19 of 83 patients showed normal myocardial uptake on planar scintigraphy and SPECT. On the remaining 64 patients, 47 had decreased myocardial uptake on both planar imaging and SPECT (group A) and 17 had reduced myocardial uptake only on SPECT, but normal finding on planar scintigraphy (group B). SPECT had a diagnostic yield for Parkinson’s disease of 77.1% compared with 56.6% for planar imaging (p<0.001). H/M ratio from planar imaging for group A and B was 1.41±0.15 (1.20~1.53) and 1.43±0.16(1.26~1.56), respectively and showed no significant difference between the two group (p=0.23). L/M ratio for group A and B was 1.58±0.19(1.3~1.78) and 2.16±0.20 (1.96~2.37), respectively and significantly higher in B group (p=0.001).

I-123 MIGB SPECT has a significantly higher diagnostic yield for Parkinson disease than planar image. Increased lung uptake may cause false negative on planar imaging.

Recently MIBG scan is important method for diagnosis of Parkinson’s disease. However the false negative rate is high on planar imaging. Rather than planar imaging using SPECT images would be excellent.

Chung, Y, Yoon, S, Song, I, Oh, J, Kim, K, Evaluation of Diagnostic Yield for Parkinson’s Disease: Comparison of Planar and SPECT Imaging.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14001262.html