Friedrich D. Knollmann MD, PhD, Presenter: Nothing to Disclose

1) To identify suitable indications for the use of CT perfusion imaging in lung cancer. 2) To apply CT perfusion imaging to lung tumors. 3) To recognize important features of a valid CT perfusion imaging protocol. 4) To interpret the results of a CT perfusion study in lung tumors.

CT perfusion (CTP)  imaging has become a tenable proposition with the advent of multislice CT. Preliminary data have indicated a potential role in the assessment of treatment response in lung cancer, but the method is not widely used. In this course, the rationale for using CT perfusion imaging as a quantitative imaging biomarker  in lung cancer is discussed. A review of CT protocols includes factors that have impeded a wider adoption of the method in the clinical sphere, such as the reproducibility of measurements, and validation efforts. Solutions to these problems, such as improved anatomic coverage with wider detectors and table motion, reduced radiation exposure with iterative reconstruction, advanced postprocessing with dual blood supply algorithms, motion registration and correction, and volumetric perfusion analysis are addressed. With these methods,  tumor classification, assessment of tumor response, and prognostic testing are promising applications of CTP imaging.

Knollmann, F, CT Perfusion Imaging in Lung Cancer.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14000763.html