So Hwa Yoon, Presenter: Nothing to Disclose

Yong-An Chung MD, PhD, Abstract Co-Author: Nothing to Disclose

In Uk Song, Abstract Co-Author: Nothing to Disclose

Kijun Kim, Abstract Co-Author: Nothing to Disclose

Jin Kyung Oh MD, Abstract Co-Author: Nothing to Disclose

Recent clinical and research interests have focused on mild cognitive impairment (MCI) as a prodrome of Alzheimer’s disease (AD) in the prevention of clinical progression. Moreover, some groups have focused on the detection and management of subjective memory impairment (SMI) as the stage that precedes MCI. However, there have been few clinical studies that have examined biomarkers of SMI to date. Therefore, in this study we investigated differences in glucose metabolism as a prodromal marker of dementia in patients with SMI, MCI, and healthy controls using brain FDG-PET.

We recruited 68 consecutive patients with SMI, 47 patients with MCI, and 42 age-matched healthy subjects. All subjects underwent FDG-PET and detailed neuropsychological testing. FDG-PET images were analyzed using the SPM program.

FDG-PET analysis showed reduced glucose metabolism in the periventricular regions of patients with SMI and in the parietal, precentral frontal, and periventricular regions of patients with MCI compared with healthy controls. Interestingly, hypometabolism on FDG-PET was noted in the parietal and precentral frontal regions in MCI patients compared to SMI patients.

Our results suggest that hypometabolism in the periventricular regions as seen on FDG-PET may play a role as a predictive biomarker of pre-dementia, and the extension of reduced glucose metabolism into parietal regions likely reflects progression of cognitive decline.

We investigated differences in glucose metabolism in patients with SMI, MCI, and healthy controls using brain FDG-PET as a potential prodromal biomarker of progression to dementia. An early, accurate diagnosis of prodromal dementia may be valuable since it could allow for proper management and prevent progression to dementia.

Yoon, S, Chung, Y, Song, I, Kim, K, Oh, J, Alteration Patterns of Brain Glucose Metabolism: Comparisons of Subjective Memory Impairment, Mild Cognitive Impairment and Healthy Controls.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/14000373.html