Peter L. Choyke MD, Presenter: Researcher, Koninklijke Philips NV Researcher, General Electric Company Researcher, Siemens AG Researcher, iCAD, Inc Researcher, Aspyrian Therapeutics, Inc Researcher, ImaginAb, Inc Researcher, Aura

1) To identify the key genetic aspects of von Hippel Lindau (VHL) disease and their relevance to treatment. 2) To distinguish radiologic features of VHL from other hereditary renal cancers. 3) To explain the implications of hereditary renal cancers for sporadic renal cancers.

Hereditary renal cancers include clear cell carcinomas associated with von Hippel Lindau Disease (VHL),  chromophobe carcinomas associated with Birt Hogg Dube,  papillary carcinomas associated with hereditary papillary cancer syndrome and type II papillary carcinomas associated with Hereditary Leiomyoma-Renal Carcinoma (HLRC) syndrome.  Additional rare syndromes exist.   This talk will focus on the distinguishing features of each entity from a radiologic perspective but also will describe the lexicon underlying the description of the genetics of these entities.   This should enable the participant to understand the "language" of genetics when describing hereditary entities in general, including terms such as tumor suppressor gene, oncogene, hypoxia inducible factor and metabolomics.  The participant should come away with a fuller understanding of these hereditary entities and their implications for more common, sporadically occurring renal cancers.

Choyke, P, Von Hippel Lindau and Other Hereditary Renal Cancer Syndromes.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/13010491.html