Edgar A. Deyoe PhD, Presenter: Stockholder, Prism Clinical Imaging, Inc Board of Directors, Prism Clinical Imaging, Inc

1) Review the functional organization of the human visual cortex. 2) Become familiar with state-of-the-art methods for presurgical mapping of the visual system with fMRI. 3) Learn of new methods for visualizing and interpreting fMRI brain maps of the visual system. 4) Become aware of interpretational issues such as neurovascular uncoupling that can significantly affect interpretation in a presurgical mapping context.

The complexity of MRI technology and the wealth of new information it provides can leave clinicians hard pressed to stay abreast of the latest developments and applications, especially since the field continues to evolve at a brisk pace. The goal of this session will be to review clinically relevant aspects of fMRI methods and their use in mapping the visual system to aid diagnosis of vision-related CNS diseases and to assist treatment planning, delivery and followup. The session will include a review of fundamental organizational principles of the human visual system with an emphasis on those properties that may be particularly relevant for clinical applications. Some principles, such as retinotopic organization may be generally familiar, but the ability to map this organization in detail quantitatively in individual patients and its utility in specific clinical applications is likely to be novel. Unique methods will be described for visualizing this organization both within the brain and as it relates to the patient’s visual field and scotomata. The session will describe specific clinical applications of visual system mapping with fMRI and will present case studies to highlight such applications. Also, included is a description of methodology aimed at streamlining the clinical workflow and highlighting practical issues that should be considered to obtain high quality data with clinical patients. The overall goal is to show how it is possible to spend as little as 10 minutes of fMRI scan time yet obtain information that can be invaluable for diagnosis and treatment of patients with brain tumors, arteriovenous malformations, epilepsy and other pathologies that can impact central visual pathways.

Deyoe, E, More Quantitative fMRI Paradigms for Presurgical Mapping of the Visual System.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/12020965.html