Edward F. Jackson PhD, Presenter: Nothing to Disclose

1) Understand selected applications of quantitative MR imaging biomarkers, particularly DCE-MRI applications. 2) Understand the factors that currently limit widespread acceptance and use of such quantitative MR imaging biomarkers, including sources of bias and variance. 3) Understand some of the current initiatives focused on the standardization, qualification, and validation of selected quantitative MR imaging biomarkers.

Clinical and clinical research applications of quantitative anatomical and functional MR imaging biomarkers, including those focused on treatment assessment, have continued to dramatically expand.  Studies at single centers have clearly demonstrated the potential of such applications.  However, sources of bias and variance of quantitative MR imaging biomarkers have not previously been adequately investigated, thus limiting the implementation of robust methods to mitigate their effects.  Therefore, when it comes to applications of such techniques across vendor platforms, centers, and time, challenges arise due to lack of standards, appropriate phantoms, and protocols. During the past few years, several quantitative MR imaging initiatives have been instigated.  This symposium presentation will review selected applications of quantitative MR imaging biomarkers, illustrate some of the current challenges in broadening the use of such biomarkers, and discuss some of the current initiatives of various scientific and federal organizations that are focused on the standardization, qualification, and validation of MR quantitative imaging biomarkers.  Specific examples of DCE-MRI applications and standardization efforts will be provided.  

web.me.com/efjackson

Jackson, E, The Physical Principles and Challenges of Dynamic Contrast Enhanced MRI Applications.  Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL. http://archive.rsna.org/2014/12020939.html