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One advantage of IGRT is the potential for reducing margins. Clinical margins are typically determined in one of 3 ways: (1) Use same margins as before (pre-IGRT), (2) Reduce margins based on ‘supposed’ improvement in accuracy/precision, perhaps based on published data, or (3) Evaluate institutions own uncertainties, and establish appropriate margins. The first two are probably the most common. However, each of these approaches has its own pitfalls: (1) does not take full advantage of our new technologies, (2) is fraught with potential error, including the fact that many published works do not adequately assess uncertainties, and (3) can be difficult, and not all physicists have the background knowledge to do this. In this presentation we will describe some practical approaches to using margin formulae and other methods used to determine safe clinical margins. The limitations, risks and pitfalls will be described.
Pollard, J,
Approaches to Using Margins to Mitigate Uncertainties. Radiological Society of North America 2014 Scientific Assembly and Annual Meeting, - ,Chicago IL.
http://archive.rsna.org/2014/12020060.html