Hao Sun MD, Presenter: Nothing to Disclose

Huadan Xue MD, Abstract Co-Author: Nothing to Disclose

Xuan Wang MD, Abstract Co-Author: Nothing to Disclose

Yu Chen MD, Abstract Co-Author: Nothing to Disclose

Yonglan He MD, Abstract Co-Author: Nothing to Disclose

Zhengyu Jin MD, Abstract Co-Author: Nothing to Disclose

To prospectively evaluate the ability to in vivo differentiate calcium oxalate and uric acid composition in urinary calculi by using dual-source dual-energy CT.

Patients referred for clinically-indicated dual-source dual-energy CT (DsDeCT) for urinary stone composition analysis whose stones were subsequently surgically removed were enrolled. DsDeCT images were processed using a custom-developed software tool that could in vivo discriminate four compositions: uric acid, cystine, hydroxylapatite and oxalat. Stone compositions were determined using DsDeCT data were compared to the reference standard (fourier transform infrared spectrometry).

Fourty urinary stones from 40 patients (30 male, 10 female, mean age: 46 years) were included in this study. There are 14 stones with single composition (uric acid n=4, cystine n=1, hydroxylapatite n=4, calcium oxalate monohydrate n=5) and 26 stones with mixed composition. The overall accuracy by using DsDeCT data alone provided 92.5% accuracy. The accuracy for identifying uric acid (n=4), cystine (n=1), hydroxylapatite (n=28) and oxalat (n=30) were 100%, 100%, 92.9% and 100%.

Unenhanced DsDeCT can help differentiate between four urinary calculi compositions with high accuracy, especially for calcium oxalate and uric acid compositions.

Unenhanced DsDeCT can in vivo differentiate four urinari stone compositions accurately, that can help physicians optimize therapeutic decisions.

Sun, H, Xue, H, Wang, X, Chen, Y, He, Y, Jin, Z, Improved Differentiation of Calcium Oxalate and Uric Acid Composition in Urinary Calculi with Dual-source Dual-energy CT.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13044350.html