Ragyoung Yoon MD, Presenter: Nothing to Disclose

Sang Joon Kim MD, Abstract Co-Author: Nothing to Disclose

Deok Hee Lee, Abstract Co-Author: Nothing to Disclose

Ho Sung Kim, Abstract Co-Author: Nothing to Disclose

Jae Seung Kim, Abstract Co-Author: Nothing to Disclose

Choong Gon Choi MD, Abstract Co-Author: Nothing to Disclose

Jungsu Oh, Abstract Co-Author: Nothing to Disclose

Dae Yoon Kim, Abstract Co-Author: Nothing to Disclose

To investigate different iron-deposition patterns of Parkinson’s disease (PD) and multiple system atrophy (MSA) in the putamen by using susceptibility-weighted images (SWI), and to correlate them with 18F-FDG PET findings.

Thirty patients with PD twenty-six with MSA (11 with MSA-P, 15 with MSA-C), and thirty-two age-matched healthy controls underwent 3-T magnetic resonance imaging with SWI of the brain. 18F-FDG PET studies were obtained in patients with PD and MSA.. Signal intensity (SI) was measured on SWI in the posterior half of the putamen using region of interest (ROI) in both sides and normalized by SI of the CSF. 18F-FDG PET images were coregistered to SWI using SPM-5 and standardized uptake value (SUV) was measured in the putamen using ROI mask obtained in SWI. Normalization of SUV was done using mean global cortical metabolism measured in each patient. Dominant hypointense side of the putamen on SWI was chosen for statistical analysis. Analysis included group-level comparison of SWI SI values of ROI , and these results were correlated with 18F-FDG PET data in PD and MSA patients.

Hypointensity of the posterior putamen was different between MSA and PD group (p=0.010). Especially, patients with MSA-P had significantly lower SI in the posterior putamen compared with those with PD, MSA-C and healthy control group (p<0.000, =0.001, <0.000, respectively). There was moderate positive correlation between SI on SWI and SUV on 18F-FDG PET in MSA (r=0.68, p <.000).

Signal intensity in the posterior putamen may differentiate MSA-P from PD, MSA-C and healthy controls. There was moderate correlation between SI on SWI correlate with metabolism on 18F-FDG PET in MSA. Out study suggests that SWI SI in the posterior putamen well-correlated with metabolism of 18F-FDG PET in patients with MSA and we speculate that iron deposition may have relationhsip with decreased metabolism.

SWI showed different patterns of brain iron deposition in clinically diagnosed groups of PD and MSA, and may be useful in discrimitating these conditions as is 18F-FDG PET.

Yoon, R, Kim, S, Lee, D, Kim, H, Kim, J, Choi, C, Oh, J, Kim, D, Utility of Susceptibility-weighted MRI in Differentiating Parkinson’s Disease and Multiple System Atrophy: Correlation with 18F-FDG PET.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13044217.html