Ansgar Malich MD, Presenter: Nothing to Disclose

Sylvia Mikulik, Abstract Co-Author: Nothing to Disclose

Klaus Thomas, Abstract Co-Author: Nothing to Disclose

Peter Hannemann, Abstract Co-Author: Nothing to Disclose

Ulf Karl Martin Teichgraeber MD, Abstract Co-Author: Nothing to Disclose

Recently developed CAD-software has the potential to quantify and differentiate obstructive and restrictive diseases of the lung based on MS-CT data and reflect some important functional parameter of the lung.

MS-CT currently does not offer functional parameter of the lung. Study aimed to analyze, whether there are parameters obtainable from CT-data reflecting functional parameters calculated by whole-body plethysmography.

100 patients were randomly selected who underwent MS-CT (128 row-CT) and whole body plethysmography (master-screen body, Jaeger, Germany) within < 7days. All data were analyzed using CAD (MeVISPulmo3D, Fraunhofer MeVis, Germany). Vital capacity (VC), FEV1, intrathoracal gas volume (ITGV), residual volume (RV), total lung capacity (TLC) were matched with CAD-based lung volume analysis (vol), mean low density (MLD), low and high attenuation values (LAV/HAV), lung weight (w) P15, PK (maximum of histogram) and FWHM (full width half max). Central obstruction, peripheral obstruction, restrictive diseases and emphysematic patients were analyzed.

CAD-analysis was possible in all cases. Acquisition time was approx. 1 minute per case. Correlation coefficients of VC were: Vol:r=.57,p<0.01; weight:r=0.61,p<0.001; MLD:r=-0.27,p<0.007; PK:r=-0.24,p<0.01; P15:r=-0.26,p<0.01; HAV:r=-0.28,p<0.006; LAV:r=0.08,p<0.45;FWHM:r=-0.10;p<0.31. ITGV correlates with Vol:r=0.71,p<0.01; LAV:r=0.45,p<0.01; MLD:r=-0.58,p<0.01, weight:r=0.31,p<0.02, FWHM:r=-0.17,p<0.1. RV showed association to Vol.:r=0.6,p<0.01; LAV:r=0.38,p<0.001, MLD:r=-0.55, p<0.01, HAV:r=-0.50,p<0.01; P15:r=-0.47,p<0.01 FEV1 showed a correlation to vol:r=-0.67,p<0.01 and LAV:r=-0.52,p<0.01, MLD:r=0.55,p<0.01, HAV:r=0.45,p<0.01; PK:r00.49,p<0.001; P15:r=0.56,p<0.001 Correlation coefficients of TLC vs. vol.,weight, MLD, HAV, PK and P15 were: r=0.83; r=0.51; r=-0.60; r=-0.56; R=-0.45; r=-0.52, all p-values <0.001. Only moderate correlation were observed for maximum exspiratory flow (PEF) and exspiratory reserve volume (ERV). Severity of obstructive and restrictive diseases showed different CAD-based data of volume, MLD, LAV and HAV (Oneway Anova, p<0.01).  

Malich, A, Mikulik, S, Thomas, K, Hannemann, P, Teichgraeber, U, Comparison of MS-CT and Whole-body Plethysmography: Is There Any Functional Information Available Using a Postprocessing with a Recent CAD-development?.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13028743.html