Jiong Zhu MD, PhD, Presenter: Nothing to Disclose

Hongxia Gong, Abstract Co-Author: Nothing to Disclose

Jianrong Xu, Abstract Co-Author: Nothing to Disclose

To evaluate the role of quantitative iodine-based material decomposition images with spectral CT in predicting the disease activity of Crohn's disease(CD)

63 patients with a proven diagnosis of CD participated in this prospective study. CD was diagnosed by clinical, enteroscopic and pathologic manifestations. Clinical remission was identified by experienced gastroenterologists using the criteria of clinical, endoscopy and laboratory tests. All patients underwent CT enterography (CTE) with spectral imaging mode on a GE Discovery CT750HD scanner. The iodine densities of disorder bowel walls, which were normalized to those of the psoas muscle, were measured and statistically compared on iodine-based material-decomposition CT images. The ROI sizes range from 15 mm2 to 30 mm2 based on the lesion size. The iodine densities were measured on both arterial phase (AP) and venous phase (VP). The two-sample t test was performed to compare quantitative parameters between active and remittent CD.

A total of 44 disorder bowel segments were detected on CTE in 19 patients to have active disease(n=44), while 49 segments were detected in 23 patients to be remission(n=49).There was a significant difference for the normalized iodine density of the bowel wall between the patients to have active CD [4.66mg/mL(3.37 to 7.09 mg/mL)] and the patients to be remission [2.59mg/mL(1.00 to 3.80 mg/mL)] on AP(DF=40 P < 0.0001). And there was also a significant difference of the bowel wall iodine density between the patients with active CD [3.75 mg/mL(1.91-6.63 mg/mL)] and those to be remission [2.78 mg/mL(1.76-3.55 mg/mL)] on VP (DF=40 P = 0.0001).

It is feasible to perform quantitative iodine-based material decomposition images with spectral CT for evaluation of CD, and this method may be used as a predictor in distinguishing active and remittent CD.  

Quantitative iodine-based material decomposition images with spectral CT can be used to evaluate the activity of Cronh’s disease.

Zhu, J, Gong, H, Xu, J, Quantitative Iodine-based Material Decomposition Images with Spectral CT for Assessment of Activity in Crohn's Disease.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13027800.html