E Rang Song, Presenter: Nothing to Disclose

Keum Won Kim MD, Abstract Co-Author: Nothing to Disclose

Hye Young Jang, Abstract Co-Author: Nothing to Disclose

Young Jun Cho MD, Abstract Co-Author: Nothing to Disclose

Cheol Mog Hwang MD, Abstract Co-Author: Nothing to Disclose

Dae Ho Kim, Abstract Co-Author: Nothing to Disclose

Dong Ki Cho MD, Abstract Co-Author: Nothing to Disclose

Minjae Yoon, Abstract Co-Author: Nothing to Disclose

To correlate 18F-fluorodeoxyglucose (FDG) maximum standardized uptake value (SUVmax) and diffusion-weighted imaging (DWI) apparent diffusion coefficient (ADC) for clinicopathological prognostic factors and to compare the prognostic value of these indexes in breast cancer.

50 breast cancers of 49 patients (age range :　37 - 83 years, mean age : 53 years) who underwent preoperative FDG PET/CT and DWI, were studied retrospectively. The breast cancers included 4 ductal carcinoma in situ (DCIS) and 46 invasive ductal carcinomas (IDC). The relationships both SUVmax and ADC with clinicopathological prognostic factors (age, tumor size, invasiveness, histologic grade, nodal metastasis, ER receptor status, PR receptor status, and HER-2 neu status) were evaluated by univariate and multivariate regression analysis and the degree of correlation was determined by Spearman’'s rank test. The patients were divided into a better prognosis group (n=16) and a worse prognosis group (n=34) based on invasiveness (DCIS or IDC) and the modified Nottingham prognostic index (NPI). Their prognostic values were examined by receiver operating characteristic (ROC) analysis.

SUVmax was significantly associated with histological grade and tumor size (p<0.05). And ADC was significantly associated with tumor size, invasiveness, histologic grade, and nodal metastasis status (p<0.05). SUVmax and ADC were negatively correlated each other (ρ = −0.45, p = 0.001). SUVmax was positively correlated with histological grade (p<0.05). ADC was negatively correlated with invasiveness, nodal metastasis status, and histological grade (p<0.05). The threshold values for predicting a worse prognosis were ≥2.75 for SUVmax (with a sensitivity, specificity and accuracy of 73.5%, 87.5% and 78%, respectively), ≤0.845 for ADC (85.3%, 81.3% and 84%) and ≥3.143 for SUVmax/ADC (76.5%, 87.5% and 80%).

SUVmax and ADC correlated with invasiveness, histologic grade, and nodal metastasis status. And these indexes are negatively correlated each other and possible to predict the prognosis of breast cancer

FDG PET-CT and diffusion-weighted imaging (DWI) predict the prognosis of breast cancer  

Song, E, Kim, K, Jang, H, Cho, Y, Hwang, C, Kim, D, Cho, D, Yoon, M, Diffusion-weighted Imaging and 18F-fluorodeoxyglucose (FDG) PET/CT for Breast Cancer: Prognostic Value of Apparent Diffusion Coefficient (ADC) and Maximum Standardized Uptake Value (SUVmax) of Breast Cancer  .  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13022044.html