Krishan Kumar Jain MD, Presenter: Nothing to Disclose

Anoop Kumar Pandey MD, Abstract Co-Author: Nothing to Disclose

Bhaswati Roy, Abstract Co-Author: Nothing to Disclose

Sandeep Vaishya MChir, MS, Abstract Co-Author: Nothing to Disclose

Rana Patir MChir, MS, Abstract Co-Author: Nothing to Disclose

Rakesh K. Gupta MD, MBBS, Abstract Co-Author: Nothing to Disclose

To assess the disease load in patients who presented with localized symptoms related to infective or neoplastic etiology with whole body MR imaging (WB-MRI) using a combination of diffusion-weighted whole-body (DWIBS) and post contrast 3D m-Dixon imaging.

45 patients underwent MRI for various localized disorders. After completion of local examination including post contrast study, 3D m-Dixon and DWIBS data sets were collected at five stations to cover whole body from skull to knees in these patients. The mean additional time for WB-MRI was 25-30 minutes. Studies were read by 2 experienced radiologists.

Out of 45patients (15 females), 12 had initial diagnosis of tuberculosis (TB), 16 had neoplastic etiology and 17 did not have any significant abnormality. Out of 12 TB patients, 7 presented with localized symptoms related to spine, 3 with brain and 2 with lung involvement. Out of 7 patients with spinal involvement, 3 had disease localized to spine and other 4 had extra lesions in brain (n=1), brain with breast (n=1), lung (n=1) and lung with musculoskeletal tissues (n=1). Among 3 patients with brain involvement, 2 had disease localized to brain and 1 showed lesions in lower lobe of left lung confirmed as non-small cell lung carcinoma on biopsy. Other 2 TB patients had disease localized to lungs. In 16 patients with neoplastic etiology, 8 had disease localized to area of abnormality, 6 patients showed multiple metastatic lesions in brain, bone, lung, spleen and liver, 1 patient with pituitary tumor showed multiple bony lesions with right chest wall abscess confirmed as tubercular on aspiration and one patient previously operated for left ureteric tumor showed unrelated brain mass lesion confirmed as gliosarcoma on histopathology.

The combination of these two techniques is complimentary in providing information regarding multi-organ involvement in patients presenting with symptoms relating to the localized disease. It provides high resolution images and has potential to use as one stop imaging technique to assess the disease load in infective and neoplastic pathologies to detect multi-organ involvement.

Disease load assessment in infective and neoplastic pathologies with DWIBS and post contrast 3D m-Dixon whole body imaging in patients presenting with single organ involvement.

Jain, K, Pandey, A, Roy, B, Vaishya, S, Patir, R, Gupta, R, Utility of Combining Whole Body Diffusion with Post Contrast 3D m-Dixon Imaging to Assess the Disease Load in Patients Presenting with Single Organ Involvement.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13021627.html