Chunhui Jiang BMedSc, MMedSc, Abstract Co-Author: Nothing to Disclose

Jian Wang, Presenter: Nothing to Disclose

It is demonstrated in this study that DWI may be useful in defining the infiltration zone of glioma, especially with high B-values. Larger studies are needed to prospectively validate the utility of ADC from high B-values DWI scan as a noninvasive imaging biomarker for quantitatively measuring the infiltration zone of glioma.

To evaluate the role of the ADC value in patients with glioma (WHO II-IV) using high B-value diffusion weighted imaging (DWI), as a potential noninvasive quantitative index in defining the boundary of glioma.  

18 cases of surgical pathologically confirmed glioma underwent the DWI scan with b=1000 and 3000s/mm2 respectively in a 3T MR scanner. The ADC values of the glioma substantial zone, cerebral parenchyma within 0-10/10-20mm radium and the cerebral parenchyma of the opposite sphere are statistically analyzed by SPSS17.

There was no significant difference between ADC values of lesions and 0-10mm area (P>0.05) in 2 DWI scans, and there was significant difference between ADC values of 0-10mm area and comparing group (P<0.05), while there was no significant difference between ADC values of 0-10mm 10-20mm area (P>0.05). When b-value = 3000 s/mm2, there is statistically valid difference among ADC values of 10-20mm area, lesions and comparing group (P<0.05); When b-value =1000 s/mm2, there is statistically valid difference among ADC values of 10-20mm area and comparing area（P<0.05）.The ADC values of lesions and 0-10mm area from both of the DWI scans show homogeneity, indicating glioma infiltration. The ADC value of 10-20mm area in high B value DWI scan is validly lower than the lesions, indicating that the ADC value is more sensitive in quantitatively analyzing the infiltration zone of glioma relative to the low B value DWI scan.

Jiang, C, Wang, J, High B-value Diffusion Weighted Imaging in Defining the Infiltration Zone of Cerebral Glioma.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13021565.html