Eric Michael Blaschke MD, Presenter: Nothing to Disclose

Hiroyuki Abe MD, Abstract Co-Author: Nothing to Disclose

To evaluate the dynamic contrast enhanced MR kinetic characteristics of newly diagnosed breast cancer in molecular subtypes.

Breast MRI examinations of 200 patients with newly diagnosed breast cancer at the University of Chicago Medical Center from 2011 through 2012 were reviewed. Cases of newly diagnosed IDC were sorted by molecular subtype (17 triple negative, 7 Her2 +, 73 Luminal A/B) and lesion segmentation and kinetic analyses were performed on a dedicated workstation. For kinetic assessment, 50% and 100% thresholds were employed for display of medium and rapid uptake, respectively. Kinetic profiles in terms of percent volume for 6 kinetic types (medium-persistent, medium-plateau, medium-washout, rapid-persistent, rapid-plateau, rapid-washout) relative to the whole volume of the lesion were obtained. Statistical analysis of the kinetic profiles was performed using the student’s T-test.

Percent volume of Her2 positive lesions with greater than 50% uptake at early phase was significantly greater compared with luminal A/B (98.7 +/ - 1.14 vs. 91.5 +/- 3.05; P .0004) and all others (98.7 +/ - 1.14 vs. 91.9 +/- 2.62; P .0002). There was a nonsignificant trend towards higher >100% uptake at early phase in Her2 positive lesions versus Luminal A/B (87.3 +/- 9.77 vs. 69.3 +/- 6.94; P .11) and all other subtypes (87.3 +/- 9.77 vs. 71.4 +/- 5.87; P .199). No significant difference in uptake ratios was noted for Her2 positive vs. triple negative tumors or triple negative tumors vs. all other subtypes. No significant difference was observed in BIRADS assessment of kinetic patterns.

Her2 positive breast cancer demonstrates a unique MRI kinetic phenotype with significantly increased rapid uptake ratios compared to other molecular subtypes.

MRI kinetic phenotypes of newly diagnosed breast cancer may provide a means of predicting molecular subtype and thus aid early treatment planning.

Blaschke, E, Abe, H, MR Imaging Phenotype of Breast Cancer: Kinetic Assessment for Molecular Subtypes.  Radiological Society of North America 2013 Scientific Assembly and Annual Meeting, December 1 - December 6, 2013 ,Chicago IL. http://archive.rsna.org/2013/13015664.html