Sang Young Oh MD, Presenter: Nothing to Disclose

Kyung-Hyun Do MD, Abstract Co-Author: Nothing to Disclose

Sang Ho Choi, Abstract Co-Author: Nothing to Disclose

Eun Jin Chae MD, PhD, Abstract Co-Author: Nothing to Disclose

Sang Min Lee MD, Abstract Co-Author: Nothing to Disclose

Hyun Joo Lee, Abstract Co-Author: Nothing to Disclose

Hye Jeon Hwang MD, Abstract Co-Author: Nothing to Disclose

Eun Young Kim, Abstract Co-Author: Nothing to Disclose

Ji-Eun Kim MD, Abstract Co-Author: Nothing to Disclose

Mi Young Kim, Abstract Co-Author: Nothing to Disclose

Jae-Woo Song MD, PhD, Abstract Co-Author: Nothing to Disclose

Joon Beom Seo MD, PhD, Abstract Co-Author: Nothing to Disclose

Koun Sik Song MD, Abstract Co-Author: Nothing to Disclose

The description of CT findings of human metapneumovirus (hMPV) has been limited to a few reports. Objective of our study was to evaluate characteristic CT findings in patients with hMPV infection and correlation with clinical findings.

We retrospectively collected patients proven hMPV pneumonia with positive results of RT-PCR for hMPV via medical record search from January 2010 through December 2011(n=403). We excluded the patients with any other infectious organisms were identified. Among them, chest CT scans within 1 week period of the time of diagnosis were assessed. The CT scans were evaluated for the presence of abnormality and characterized by pattern and regional distribution; ground glass opacity (GGO), airspace consolidations, tree-in-bud opacities, centrilobular nodule, and bronchial wall thickening.

 Among 403 patients, 76 patients were included (M:F=42:34, mean 62.4year; range 19~88 year). Most patients (n=72/76, 94.7%) had underlying comorbidities; malignant diseases (n =25), diabetes (n = 15), transplantation recipients (kidney; n = 8, heart; n =3, liver; n =2), chronic obstructive lung diseases (n =5), and other chronic medical diseases (n=14). Predominant CT features were segmental distributed ill-defined centrilobular nodules (57.9%), GGO (68.4%) and consolidation (38.2%). Other findings were tree-in-bud opacities (7.9%) and bronchial wall thickening (7.9%). Four patients without underlying comorbidity showed similar CT findings with comorbidity group (GGO, centrilobular nodules, and consolidation).

Most patients with abnormal CT features had underlying medical problems, suggesting immune-compromized host conditions. The most common CT findings of hMPV pneumonia are multifocal distributed ill-defined centrilobular nodules with airspace-filling pattern, GGO and consolidation.

This study assessed characteristic CT findings of hMPV infection. Clinico-radiological correlation is useful for management and prediction of clinical outcome in patients with hMPV pneumonia.

Oh, S, Do, K, Choi, S, Chae, E, Lee, S, Lee, H, Hwang, H, Kim, E, Kim, J, Kim, M, Song, J, Seo, J, Song, K, CT Findings of Human Metapneumovirus Pneumonia: Novel Respiratory Viral Infections.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12037166.html