Tomohiro Noda, Presenter: Nothing to Disclose

Tosiaki Miyati PhD, Abstract Co-Author: Nothing to Disclose

Noam Alperin PhD, Abstract Co-Author: Stockholder, Alperin Noninvasive Diagnostics, Inc

Naoki Ohno MS, Abstract Co-Author: Nothing to Disclose

Takashi Hamaguchi PhD, Abstract Co-Author: Nothing to Disclose

Masako Takanaga, Abstract Co-Author: Nothing to Disclose

Tatsuhiko Matsushita BS, Abstract Co-Author: Nothing to Disclose

Toshifumi Gabata MD, Abstract Co-Author: Nothing to Disclose

Osamu Matsui MD, Abstract Co-Author: Nothing to Disclose

ECG synchronized phase-contrast cine-MRI (PC cine-MRI) is used for quantifying the intracranial condition such as intracranial compliance, intracranial volume change, cerebrospinal fluid flow (CSF) pressure, and applied to the diagnosis of a normal pressure hydrocephalus and Arnold-Chiari malformation. However, it takes at least several minutes to obtain the PC cine-MRI data. Therefore, to reduce burden on patients, and allow breath-hold scan for obtaining new physiological information, we shortened the acquisition time of PC cine-MRI data, and assessed its accuracy.

A fast PC cine-MRI was used with segmented k-space method (segment = 2), sensitivity encoding (reduction factor = 2), and rectangular field of view to reduce scan time within 30 seconds in each velocity encoding (VENC). On a 3-T MRI, we first set a transverse slice at the mid-C2 level in six healthy volunteers, and twice obtained velocity-mapped phase images with different VENC of for CSF flow (VENC = 7 cm/s) and transcranial blood flow (VENC = 90 cm/s) using the fast PC cine-MRI. Next we obtained intracranial compliance index (ICCI), which was defined as the ratio of the peak-to-peak intracranial volume change (ICVCp-p) to the peak-to-peak CSF pressure gradient (PGp-p) calculated from CSF and transcranial blood flow data during the cardiac cycle. Then we compared between ICCI, PGp-p, and ICVCp-p with fast PC cine-MRI and those with conventional PC cine-MRI during breathing. Moreover, we compared between those values during breath-hold with expiration and inspiration using the fast PC cine-MRI.

ICCI, PGp-p, and ICVCp-p calculated from fast PC cine-MRI were agreed with those from conventional PC cine-MRI (ICCI, R2=0.89, P<0.01; PGp-p, R2=0.92, P<0.01; ICVCp-p, R2=0.82, P<0.05). PGp-p with inspiration using fast PC cine-MRI was significantly larger than that with expiration, and this result might provide new physiological information such as compensatory faculty of increase in the intracranial pressure.

The fast PC cine-MRI makes it possible to noninvasively obtain information on intracranial condition within 30 seconds.

The fast PC cine-MRI makes it possible to noninvasively obtain information on intracranial condition within 30 seconds, and thereby allows reduction in burden on patients and breath-hold scan.

Noda, T, Miyati, T, Alperin, N, Ohno, N, Hamaguchi, T, Takanaga, M, Matsushita, T, Gabata, T, Matsui, O, Fast Phase-Contrast Cine-MRI for Assessing Intracranial Condition.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12036530.html