Filippo Cademartiri MD, PhD, Abstract Co-Author: Speakers Bureau, Bracco Group

Erica Maffei MD, Abstract Co-Author: Nothing to Disclose

Marco Francone MD, Presenter: Nothing to Disclose

Sara Seitun MD, Abstract Co-Author: Nothing to Disclose

Teresa Arcadi MD, Abstract Co-Author: Nothing to Disclose

Massimo Midiri MD, Abstract Co-Author: Nothing to Disclose

Marco Rengo MD, Abstract Co-Author: Nothing to Disclose

Vincenzo Russo MD, Abstract Co-Author: Nothing to Disclose

Carlo Tedeschi, Abstract Co-Author: Nothing to Disclose

Andrea Guaricci MD, Abstract Co-Author: Nothing to Disclose

To assess the prognostic value of 64-slice coronary computed tomography angiography (CCTA) in relation to age and gender.

We evaluated a cohort of 1.163 patients without known CAD who underwent a 64-slice CCTA. The primary endpoint was the occurence of myocardial infarction, hospitalization for unstable angina and death from all causes. Univariable and multivariable Cox proportional hazards models were developed to assess potential predictors.

546 patients had ≥65 years (262 male) and the remaining 617 had <65 years (399 male). The prevalence of normal coronary arteries was 42% (n=489), whereas the prevalence of either non-significant (1%-49% stenosis) and significant (≥50%) CAD was 29% (respectively n=339 and n=335). At a mean follow-up of 831.8±310 days, 62 events had occurred (5.3%). In risk-adjusted analysis, obstructive (p<0.0001) and nonobstructive (p=0.04) CAD conferred increased risk compared with patients without evident CAD. Furthermore, the number of diseased segments (p=0.006), and the number of segments (p=0.04) and vessels (p=0.003) with significant CAD were indipendent prognostic indicators. No significant differences in outcome were observed between male and female patients in each age categories (< or ≥65 years). Significant CAD was also an indipendent predictor of events for both patients with <65 years and ≥65 years and in male, but not for female patients. However, for female patients indipendent predictors were the number of vessels (p=0.01) and segments (p=0.01) with significant CAD.

Presence of significant CAD is associated with a poor prognosis. CCTA has the potential to improve risk stratification according to age and gender.

CTCA is a valid tool for the diagnosis of obstructive CAD and also for a proper cardiovascular risk stratification

Cademartiri, F, Maffei, E, Francone, M, Seitun, S, Arcadi, T, Midiri, M, Rengo, M, Russo, V, Tedeschi, C, Guaricci, A, Prognostic Value of Coronary Computed Tomography Angiography Related to Age and Gender: Results from the PRORECAD Registry.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12036234.html