Chao Chen, Abstract Co-Author: Nothing to Disclose

Qi Liu, Abstract Co-Author: Nothing to Disclose

Jianping Lu MD, Presenter: Nothing to Disclose

Qiang Hao, Abstract Co-Author: Nothing to Disclose

Bing Xu, Abstract Co-Author: Nothing to Disclose

Bing Tian MD, Abstract Co-Author: Nothing to Disclose

By 640-slice dynamic volume CT (640CT) perfusion of renal cortex and kidney tumors, to compare the microcirculatory difference of some types of kidney tumors pathologically.

Dynamic contrast-enhanced perfusion imaging with 640CT was prospectively performed before surgery in 46 cases histologically proven kidney tumors including clear cell RCC(renal cell carcinoma)(n=29), papillary type RCC(n= 6), chromophobic cell RCC(n=2), and renal angiomyolipoma(RAML)(n=9). BV (Blood volume), PS (clearance), and BF(Blood flow) of tumor and normal renal cortex were measured and statistically analyzed.

The mean BV, PS, and BF of normal renal cortex, clear cell RCC, papillary type RCC, chromophobic cell RCC, and RAML were showed as follows. The mean BV of normal renal cortex and the four types of tumors were (131.9±18.7 )ml/100ml, (72.7±7)ml/100ml, (48.2±6.4)ml/100ml, (110.8±26.2) ml/100ml, and (33.3±3.9)ml/100ml respectively. The mean PS(clearance) of normal renal cortex and the four types of tumors were (197.4±60.6)ml/100ml/min, (100.8±24)ml/100ml/min, (52.2±13.2)ml/100ml/min, (78.6±41.4)ml/100ml/min, and (34.2±11.4)ml/100ml/min respectively. The mean BF of normal renal cortex and the four types of tumors were (321.7±6)ml/100ml/min, (167.0±20.6)ml/100ml/min, (83.5±29.4)ml/100ml/min, (225.2±16.7)ml/100ml/min, and (302.3±10.9)ml/100ml/min respectively. The BV, PS, and BF of kidney tumors were lower than that of normal renal cortex (P<0.01). Compared with papillary type RCC, the BV, PS, and BF of clear cell RCC were higher (P<0.05). Compared with chrornophobic cell RCC, the BV, PS, and BF of clear cell RCC were lower. Compared with RAML, the BV and BF of clear cell RCC were higher and PS was lower.

The imaging of perfusion by 640CT has high quality and shows hemodynamic features of the whole kidney and kidney tumors, which can help to provide exact perfusion parameters. Perfusion differences between kidney tumor and normal renal parenchyma could be directly assessed by 640CT. There are obvious differences showing on perfusion imaging of different pathological types of kidney tumors.

640CT perfusion imaging is valuable in diagnosis of renal tumors, and will promote the development of renal CT perfusion in the future.

Chen, C, Liu, Q, Lu, J, Hao, Q, Xu, B, Tian, B, Study on  640-slice Dynamic Volume CT Perfusion in Different Pathological Types of Kidney Tumors.  Radiological Society of North America 2012 Scientific Assembly and Annual Meeting, November 25 - November 30, 2012 ,Chicago IL. http://archive.rsna.org/2012/12036176.html